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GSK3β-IN-2

CAT: 0931-T205461-01Size: 10 mgDry Ice: NoHazardous: No
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CAT#:0931-T205461-01Size:10 mg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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CAS Number
3068378-38-8
Target
Wnt/beta-catenin, GSK-3
Related Pathways
Cytoskeletal Signaling, Stem Cells, PI3K/Akt/mTOR signaling
Bioactivity
GSK3β-IN-2 (Compound S01) is an inhibitor of GSK3β with an IC50 of 0.35 nM. It activates the Wnt/β-catenin signaling pathway, promoting neurogenesis and neurite outgrowth. GSK3β-IN-2 reduces tau protein phosphorylation induced by Aβ at the Ser396 site, thereby decreasing neurofibrillary tangles. Furthermore, GSK3β-IN-2 improves Alzheimer's disease symptoms in a zebrafish model.
Smiles
O=C(NC=1C=NC=CC1C=2C=CC=CC2)C3=CNC4=NC=C(C=C43)C=5C=CC=CC5
Molecular Formula
C25H18N4O
Molecular Weight
390.437
Shipping Conditions
Ice Packs
Storage Temperature
-20°C

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