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GSK3β-IN-2

CAT: 0804-HY-172171-01Size: 5 mgDry Ice: NoHazardous: No
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CAT#:0804-HY-172171-01Size:5 mg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
GSK3β-IN-2 (Compound S01) is the inhibitor for GSK3β with an IC50 of 0.35 nM. GSK3β-IN-2 activates Wnt/β-catenin signaling pathway, promotes neurogenesis and neurite growth. GSK3β-IN-2 inhibits Aβ-induced tau hyperphosphorylation at Ser396, reduces the formation of neurofibrillary tangles. GSK3β-IN-2 ameliorates Alzheimer's Disease in zebrafish model[1].
CAS Number
3068378-38-8
UNSPSC
12352005
Target
GSK-3; Wnt; β-catenin
Related Pathways
PI3K/Akt/mTOR; Stem Cell/Wnt
Field of Research
Neurological Disease
Concentration
10mM
Purity
98.75
Solubility
DMSO : 100 mg/mL (ultrasonic)
Smiles
O=C(C1=CNC2=NC=C(C3=CC=CC=C3)C=C21)NC4=C(C5=CC=CC=C5)C=CN=C4
Molecular Formula
C25H18N4O
Molecular Weight
390.44
References & Citations
[1]Xun QQ, et al., Identification of a novel pyrrolo[2,3-b]pyridine compound as a potent glycogen synthase kinase 3β inhibitor for treating Alzheimer's disease. J Enzyme Inhib Med Chem. 2025 Dec;40 (1) :2466846.
Shipping Conditions
Blue Ice
Storage Conditions
-20°C, 3 years (Powder)
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Isoform
GSK-3β

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