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GSK3β-IN-3

CAT: 0931-T210567-01Size: 10 mgDry Ice: NoHazardous: No
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CAT#:0931-T210567-01Size:10 mg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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CAS Number
301359-45-5
Target
GSK-3, Cytochromes P450
Related Pathways
PI3K/Akt/mTOR signaling, Stem Cells, Metabolism
Bioactivity
GSK3β-IN-3 is an ATP-competitive GSK-3β inhibitor (IC50= 0.90 μM) that demonstrates good blood-brain barrier permeability (Pe= 10.7 x 10^-6 cm/s) . It effectively reduces tau protein phosphorylation in the BR5706 strain and decreases Aβ aggregate deposition in the CL2006 strain, indicating its potential as a candidate for Alzheimer's disease (AD) research.
Smiles
O=C(OCC)C1=C(NC(=S)NC1C=2C=CC=CC2Cl)C
Molecular Formula
C14H15ClN2O2S
Molecular Weight
310.8
Shipping Conditions
Ice Packs
Storage Temperature
-20°C

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