AMG-780

• Description:

  AMG-780 is a fully human IgG2 antibody that targets angiopoietin 1 (Ang1) (IC50 = 4.5 nM) and angiopoietin 2 (Ang2) (IC50 = 0.06 nM) . AMG-780 inhibits tumor growth in the Colo205 xenograft mouse model by inhibiting both Ang1 and Ang2. AMG-780 is indicated for the research of cancers such as colon cancer[1][2].

• UNSPSC:

  12352100

• Target:

  Tie

• Related Pathways:

  Protein Tyrosine Kinase/RTK

• Field of Research:

  Cancer

• References & Citations:

  [1]James V. Bready, et al. Abstract 1022: Development and preclinical testing of AMG 780, a fully human antibody targeting angiopoietin 1 (Ang1) and angiopoietin 2 (Ang2) . Cancer Res 1 October 2014; 74 (19_Supplement) : 1022. |[2]James V. Bready, et al. Abstract 1022: Development and preclinical testing of AMG 780, a fully human antibody targeting angiopoietin 1 (Ang1) and angiopoietin 2 (Ang2) . Cancer Res 1 October 2014; 74 (19_Supplement) : 1022.

• Shipping Conditions:

  Room temperature

• Scientific Category:

  Inhibitory Antibodies

• Clinical Information:

  No Development Reported