CSL-360

• Description :

  CSL-360 is a chimeric unconjugated IgG1 monoclonal antibody targeting CD123. CSL-360 efficiently prevents the binding of IL-3 to CD123, abolishing IL-3 induced cell proliferation. CSL-360 can be used for acute myeloid leukemia (AML) research[1][2].

• UNSPSC :

  12352100

• Target :

  Interleukin Related

• Related Pathways :

  Immunology/Inflammation

• Field of Research :

  Cancer

• References & Citations :

  [1]Slade MJ, et al. CD123 bi-specific antibodies in development in AML: What do we know so far? Best Pract Res Clin Haematol. 2020 Dec;33 (4) :101219.|[2]Chichili GR, et al. A CD3xCD123 bispecific DART for redirecting host T cells to myelogenous leukemia: preclinical activity and safety in nonhuman primates. Sci Transl Med. 2015 May 27;7 (289) :289ra82.

• Shipping Conditions :

  Room temperature

• Scientific Category :

  Inhibitory Antibodies

• Clinical Information :

  No Development Reported

• Isoform :

  IL-13