PFE-360

• Product Name Alternative:

  PF-06685360

• UNSPSC Description:

  PFE-360 (PF-06685360) is a potent, selective, brain penetrated and orally active leucine-rich repeat kinase 2 (LRRK2) inhibitor with a mean IC50 of 2.3 nM in vivo[1][2].

• Target Antigen:

  LRRK2

• Type:

  Reference compound

• Related Pathways:

  Autophagy

• Field of Research:

  Neurological Disease

• Assay Protocol:

  https://www.medchemexpress.com/pfe-360.html

• Purity:

  99.48

• Solubility:

  DMSO : 10.42 mg/mL (ultrasonic)

• Smiles:

  N#CC1=CC(C2=CNC3=NC=NC(N4CCOCC4)=C32)=CN1C

• Molecular Weight:

  308.34

• References & Citations:

  [1]Marco A.S. Baptista, et al. LRRK2 Kinase Inhibitors of Different Structural Classes Induce Abnormal Accumulation of Lamellar Bodies in Type II Pneumocytes in Non-Human Primates but are Reversible and Without Pulmonary Functional Consequences.|[2]Andersen MA, et al. Parkinson's disease-like burst firing activity in subthalamic nucleus induced by AAV-α-synuclein is normalized by LRRK2 modulation. Neurobiol Dis. 2018 Aug;116:13-27.|[3]Andersen MA, et al. PFE-360-induced LRRK2 inhibition induces reversible, non-adverse renal changes in rats. Toxicology. 2018 Feb 15;395:15-22.

• Shipping Conditions:

  Room Temperature

• Storage Conditions:

  -20°C, 3 years; 4°C, 2 years (Powder)

• Clinical Information:

  No Development Reported

• CAS Number:

  1527475-61-1