PFE-360
CAT:
804-HY-120085-04
Size:
50 mg
Price:
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- Availability: 24/48H Stock Items & 2 to 6 Weeks non Stock Items.
- Dry Ice Shipment: No
PFE-360
- Product Name Alternative: PF-06685360
- CAS Number: 1527475-61-1
- UNSPSC Description: PFE-360 (PF-06685360) is a potent, selective, brain penetrated and orally active leucine-rich repeat kinase 2 (LRRK2) inhibitor with a mean IC50 of 2.3 nM in vivo[1][2].
- Target Antigen: LRRK2
- Type: Reference compound
- Related Pathways: Autophagy
- Field of Research: Neurological Disease
- Assay Protocol: https://www.medchemexpress.com/pfe-360.html
- Purity: 99.48
- Solubility: DMSO : 10.42 mg/mL (ultrasonic)
- Smiles: N#CC1=CC(C2=CNC3=NC=NC(N4CCOCC4)=C32)=CN1C
- Molecular Weight: 308.34
- References & Citations: [1]Marco A.S. Baptista, et al. LRRK2 Kinase Inhibitors of Different Structural Classes Induce Abnormal Accumulation of Lamellar Bodies in Type II Pneumocytes in Non-Human Primates but are Reversible and Without Pulmonary Functional Consequences.|[2]Andersen MA, et al. Parkinson's disease-like burst firing activity in subthalamic nucleus induced by AAV-α-synuclein is normalized by LRRK2 modulation. Neurobiol Dis. 2018 Aug;116:13-27.|[3]Andersen MA, et al. PFE-360-induced LRRK2 inhibition induces reversible, non-adverse renal changes in rats. Toxicology. 2018 Feb 15;395:15-22.
- Shipping Conditions: Room Temperature
- Storage Conditions: -20°C, 3 years; 4°C, 2 years (Powder)
- Clinical Information: No Development Reported