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360A

CAT: 0804-HY-15595-01Size: 1 mgDry Ice: NoHazardous: No
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CAT#:0804-HY-15595-01Size:1 mg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
360A is a selective stabilizer of G-quadruplex, and also inhibits telomerase activity with an IC50 of 300 nM for telomerase in TRAP-G4 assay.
CAS Number
794458-56-3
UNSPSC
12352005
Hazard Statement
H302-H315-H319-H335
Target
G-quadruplex; Telomerase
Type
Reference compound
Related Pathways
Cell Cycle/DNA Damage
Applications
Cancer-programmed cell death
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/360a.html
Solubility
10 mM in DMSO
Smiles
O=C(C1=CC=CC(C(NC2=C[N+](C)=C3C=CC=CC3=C2)=O)=N1)NC4=C[N+](C)=C5C=CC=CC5=C4
Molecular Formula
C27H23N5O2
Molecular Weight
449.50
Precautions
P261-P264-P270-P271-P280-P302+P352-P304+P340-P305+P351+P338-P330-P362+P364-P403+P233-P405-P501
References & Citations
[1]Pennarun G, et al. Apoptosis related to telomere instability and cell cycle alterations in human glioma cells treated by new highly selective G-quadruplex ligands. Oncogene. 2005 Apr 21;24 (18) :2917-28.|[2]Gauthier LR, et al. Rad51 and DNA-PKcs are involved in the generation of specific telomere aberrations induced by the quadruplex ligand 360A that impair mitotic cell progression and lead to cell death. Cell Mol Life Sci. 2012 Feb;69 (4) :629-40.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported

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