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BAY 61-3606

CAT: 0804-HY-76474Size: 1 EachDry Ice: NoHazardous: No
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CAT#:0804-HY-76474Size:1 Each
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Description
BAY 61-3606 is an orally available, ATP-competitive, reversible and highly selective Syk inhibitor with a Ki of 7.5 nM and an IC50 of 10 nM[1]. BAY 61-3606 reduces ERK1/2 and Akt phosphorylation in neuroblastoma cell[2]. BAY 61-3606 induces a large decrease of Syk phosphorylation in K-rn cell lysates[3]. Bay 61-3606 sensitizes TRAIL-induced apoptosis by downregulating Mcl-1 in breast cancer cells[4].
CAS Number
732983-37-8
UNSPSC
12352005
Hazard Statement
H315-H319-H320
Target
Apoptosis; Syk
Type
Reference compound
Related Pathways
Apoptosis; Protein Tyrosine Kinase/RTK
Applications
Cancer-Kinase/protease
Field of Research
Cancer; Inflammation/Immunology
Assay Protocol
https://www.medchemexpress.com/bay-61-3606.html
Purity
98.21
Solubility
DMSO : 5 mg/mL (ultrasonic; warming; heat to 80°C)
Smiles
O=C(C1=CC=CN=C1NC2=NC(C3=CC=C(OC)C(OC)=C3)=CC4=NC=CN24)N
Molecular Formula
C20H18N6O3
Molecular Weight
390.40
Precautions
P264-P280-P302+P352-P305+P351+P338-P362
References & Citations
[3]Gioia R, et al. Quantitative phosphoproteomics revealed interplay between Syk and Lyn in the resistance to nilotinib in chronic myeloid leukemia cells. Blood. 2011 Aug 25;118 (8) :2211-21.|[4]Kim SY, et al. Bay 61-3606 Sensitizes TRAIL-Induced Apoptosis by Downregulating Mcl-1 in Breast Cancer Cells. PLoS One. 2015 Dec 31;10 (12) :e0146073.|[1]Yamamoto N, et al. The orally available spleen tyrosine kinase inhibitor 2-[7- (3,4-dimethoxyphenyl) -imidazo[1,2-c]pyrimidin-5-ylamino]nicotinamide dihydrochloride (BAY 61-3606) blocks antigen-induced airway inflammation in rodents. J Pharmacol Exp Ther. 2003 Sep;306 (3) :1174-81.|[2]Tümmler C, et al. SYK Inhibition Potentiates the Effect of Chemotherapeutic Drugs on Neuroblastoma Cells in Vitro. Cancers (Basel) . 2019 Feb 10;11 (2) . pii: E202.
Shipping Conditions
Room Temperature
Storage Conditions
-20°C, 3 years; 4°C, 2 years (Powder)
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Citation 01
Harvard Medical School LINCS LIBRARY|Hematology. 2025 Dec;30 (1) :2495221.|Int J Mol Sci. 2021 Mar 24;22 (7) :3323.|Research Square Preprint. 2024 Apr 19.|Front Immunol. 2018 Feb 15:9:249.|JCI Insight. 2024 Jun 13:e174746.|Mol Cancer Ther. 2024 Oct 1;23 (10) :1404-1417.|Neuro Oncol. 2018 Apr 9;20 (5) :621-631.|Proc Natl Acad Sci U S A. 2022 Oct 25;119 (43) :e2207280119.

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