Phlotoxin-1 (TFA)

• Description:

  Phlotoxin-1 (PhlTx1) is a 34-amino acid and 3-disulfide bridge peptide. Phlotoxin-1 can be isolated from Phlogiellus genus spider. Phlotoxin-1 is an antinociceptive agent by inhibiting NaV1.7 channel[1][2].

• Product Name Alternative:

  PhlTx1 (TFA)

• UNSPSC:

  12352209

• Target:

  Sodium Channel

• Related Pathways:

  Membrane Transporter/Ion Channel

• Applications:

  Neuroscience-Neuromodulation

• Field of Research:

  Neurological Disease

• Purity:

  92.73

• Solubility:

  DMSO : 100 mg/mL (ultrasonic)

• Smiles:

  O=C ([C@@H] (N) C) N[C@H] (C (N[C@H] (C (NCC (N[C@H] (C (N[C@H] (C (N[C@H] (C (N[C@H] (C (N[C@H] (C (N[C@H] (C (N1[C@H] (C (N[C@H] (C (N[C@H] (C (N[C@H] (C (N[C@H] (C (N[C@H]2CSSC[C@H] (NC3=O) C (N[C@H] (C (N[C@H] (C (N[C@H] (C (N[C@H] (C (N[C@H] (C (O) =O) CC4=CC=CC=C4) =O) CC (C) C) =O) CCCCN) =O) CC5=CC=C (O) C=C5) =O) CCCNC (N) =N) =O) =O) CCCCN) =O) CO) =O) C) =O) CCCCN) =O) CCC1) =O) CC (O) =O) =O) CSSC[C@H] (NC6=O) C (N[C@H] (C (N[C@H] (C (N[C@H] (C (N[C@H] (C (N7[C@H] (C (N[C@H]3CC8=CNC9=CC=CC=C89) =O) CCC7) =O) CC%10=CC=C (O) C=C%10) =O) CCCCN) =O) CC%11=CNC%12=CC=CC=C%11%12) =O) CCC (O) =O) =O) =O) CO) =O) CC (O) =O) =O) CC%13=CNC%14=CC=CC=C%13%14) =O) CCC (N) =O) =O) =O) CC (C) C) =O) CSSC[C@H] (NC2=O) C (N%15[C@H] (C (N[C@H] (C (N[C@H] (C (N[C@H]6C) =O) CC%16=CC=C (O) C=C%16) =O) CC (N) =O) =O) CCC%15) =O.OC (C (F) (F) F) =O.[x]

• Molecular Formula:

  C183H254N46O48S6.xC2HF3O2

• Molecular Weight:

  4058.64 (free base)

• References & Citations:

  [1]Gonçalves TC, et al. Evaluation of the Spider (Phlogiellus genus) Phlotoxin 1 and Synthetic Variants as Antinociceptive Drug Candidates. Toxins (Basel) . 2019 Aug 22;11 (9) :484.|[2]Nicolas S, et al. Chemical Synthesis, Proper Folding, Nav Channel Selectivity Profile and Analgesic Properties of the Spider Peptide Phlotoxin 1. Toxins (Basel) . 2019 Jun 21;11 (6) :367.

• Shipping Conditions:

  Blue Ice

• Storage Conditions:

  -80°C, 2 years; -20°C, 1 year (Powder, sealed storage, away from moisture)

• Scientific Category:

  Peptides

• Clinical Information:

  No Development Reported