Phlotoxin-1 (TFA)

CAT: 0804-HY-P5160ASize: 1 EachDry Ice: NoHazardous: No
CAT#:0804-HY-P5160ASize:1 Each
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Description
Phlotoxin-1 (PhlTx1) is a 34-amino acid and 3-disulfide bridge peptide. Phlotoxin-1 can be isolated from Phlogiellus genus spider. Phlotoxin-1 is an antinociceptive agent by inhibiting NaV1.7 channel[1][2].
Product Name Alternative
PhlTx1 (TFA)
UNSPSC
12352209
Target
Sodium Channel
Related Pathways
Membrane Transporter/Ion Channel
Applications
Neuroscience-Neuromodulation
Field of Research
Neurological Disease
Purity
92.73
Solubility
DMSO : 100 mg/mL (ultrasonic)
Smiles
O=C([C@@H](N)C)N[C@H](C(N[C@H](C(NCC(N[C@H](C(N[C@H](C(N[C@H](C(N[C@H](C(N[C@H](C(N[C@H](C(N1[C@H](C(N[C@H](C(N[C@H](C(N[C@H](C(N[C@H](C(N[C@H]2CSSC[C@H](NC3=O)C(N[C@H](C(N[C@H](C(N[C@H](C(N[C@H](C(N[C@H](C(O)=O)CC4=CC=CC=C4)=O)CC(C)C)=O)CCCCN)=O)CC5=CC=C(O)C=C5)=O)CCCNC(N)=N)=O)=O)CCCCN)=O)CO)=O)C)=O)CCCCN)=O)CCC1)=O)CC(O)=O)=O)CSSC[C@H](NC6=O)C(N[C@H](C(N[C@H](C(N[C@H](C(N[C@H](C(N7[C@H](C(N[C@H]3CC8=CNC9=CC=CC=C89)=O)CCC7)=O)CC%10=CC=C(O)C=C%10)=O)CCCCN)=O)CC%11=CNC%12=CC=CC=C%11%12)=O)CCC(O)=O)=O)=O)CO)=O)CC(O)=O)=O)CC%13=CNC%14=CC=CC=C%13%14)=O)CCC(N)=O)=O)=O)CC(C)C)=O)CSSC[C@H](NC2=O)C(N%15[C@H](C(N[C@H](C(N[C@H](C(N[C@H]6C)=O)CC%16=CC=C(O)C=C%16)=O)CC(N)=O)=O)CCC%15)=O.OC(C(F)(F)F)=O.[x]
Molecular Formula
C183H254N46O48S6.xC2HF3O2
Molecular Weight
4058.64 (free base)
References & Citations
[1]Gonçalves TC, et al. Evaluation of the Spider (Phlogiellus genus) Phlotoxin 1 and Synthetic Variants as Antinociceptive Drug Candidates. Toxins (Basel) . 2019 Aug 22;11 (9) :484.|[2]Nicolas S, et al. Chemical Synthesis, Proper Folding, Nav Channel Selectivity Profile and Analgesic Properties of the Spider Peptide Phlotoxin 1. Toxins (Basel) . 2019 Jun 21;11 (6) :367.
Shipping Conditions
Blue Ice
Storage Conditions
-80°C, 2 years; -20°C, 1 year (Powder, sealed storage, away from moisture)
Scientific Category
Peptides
Clinical Information
No Development Reported

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