Phlotoxin-1

• Description:

  Phlotoxin-1 (PhlTx1) is a 34-amino acid and 3-disulfide bridge peptide. Phlotoxin-1 can be isolated from Phlogiellus genus spider. Phlotoxin-1 is an antinociceptive agent by inhibiting NaV1.7 channel[1][2].

• Product Name Alternative:

  PhlTx1

• UNSPSC:

  12352209

• Target:

  Sodium Channel

• Type:

  Peptides

• Related Pathways:

  Membrane Transporter/Ion Channel

• Applications:

  COVID-19-immunoregulation

• Field of Research:

  Neurological Disease

• Assay Protocol:

  https://www.medchemexpress.com/phlotoxin-1.html

• Solubility:

  10 mM in DMSO

• Smiles:

  O=C (N[C@@H] (CSSC[C@@H] (C (N1[C@@H] (CCC1) C (N[C@@H] (CC (N) =O) C (N[C@@H] (CC2=CC=C (C=C2) O) C (N[C@H]3C) =O) =O) =O) =O) NC4=O) C (N[C@@H] (CC (C) C) C (NCC (N[C@@H] (CCC (N) =O) C (N[C@@H] (CC5=CNC6=CC=CC=C56) C (N[C@@H] (CC (O) =O) C (N[C@@H] (CO) C (N[C@@H] (CSSC[C@@H] (C (N[C@@H] (CCC (O) =O) C (N[C@@H] (CC7=CNC8=CC=CC=C78) C (N[C@@H] (CCCCN) C (N[C@@H] (CC9=CC=C (C=C9) O) C (N%10[C@@H] (CCC%10) C (N[C@H]%11CC%12=CNC%13=CC=CC=C%12%13) =O) =O) =O) =O) =O) =O) NC3=O) C (N[C@@H] (CC (O) =O) C (N%14[C@@H] (CCC%14) C (N[C@@H] (CCCCN) C (N[C@@H] (C) C (N[C@@H] (CO) C (N[C@@H] (CCCCN) C (N[C@H]4CSSC[C@@H] (C (N[C@@H] (CCCNC (N) =N) C (N[C@@H] (CC%15=CC=C (C=C%15) O) C (N[C@@H] (CCCCN) C (N[C@@H] (CC (C) C) C (N[C@@H] (CC%16=CC=CC=C%16) C (O) =O) =O) =O) =O) =O) =O) NC%11=O) =O) =O) =O) =O) =O) =O) =O) =O) =O) =O) =O) =O) =O) =O) [C@H] (C) N

• Molecular Formula:

  C183H254N46O48S6

• Molecular Weight:

  4058.64

• References & Citations:

  [1]Gonçalves TC, et al. Evaluation of the Spider (Phlogiellus genus) Phlotoxin 1 and Synthetic Variants as Antinociceptive Drug Candidates. Toxins (Basel) . 2019 Aug 22;11 (9) :484.|[2]Nicolas S, et al. Chemical Synthesis, Proper Folding, Nav Channel Selectivity Profile and Analgesic Properties of the Spider Peptide Phlotoxin 1. Toxins (Basel) . 2019 Jun 21;11 (6) :367.

• Shipping Conditions:

  Room temperature

• Scientific Category:

  Peptides

• Clinical Information:

  No Development Reported