Phlotoxin-1

• UNSPSC Description:

  Phlotoxin-1 (PhlTx1) is a 34-amino acid and 3-disulfide bridge peptide. Phlotoxin-1 can be isolated from Phlogiellus genus spider. Phlotoxin-1 is an antinociceptive agent by inhibiting NaV1.7 channel[1][2].

• Target Antigen:

  Sodium Channel

• Type:

  Peptides

• Related Pathways:

  Membrane Transporter/Ion Channel

• Applications:

  COVID-19-immunoregulation

• Field of Research:

  Inflammation/Immunology

• Assay Protocol:

  https://www.medchemexpress.com/phlotoxin-1.html

• Solubility:

  10 mM in DMSO

• Smiles:

  O=C(N[C@@H](CSSC[C@@H](C(N1[C@@H](CCC1)C(N[C@@H](CC(N)=O)C(N[C@@H](CC2=CC=C(C=C2)O)C(N[C@H]3C)=O)=O)=O)=O)NC4=O)C(N[C@@H](CC(C)C)C(NCC(N[C@@H](CCC(N)=O)C(N[C@@H](CC5=CNC6=CC=CC=C56)C(N[C@@H](CC(O)=O)C(N[C@@H](CO)C(N[C@@H](CSSC[C@@H](C(N[C@@H](CCC(O)=O)C(N[C@@H](CC7=CNC8=CC=CC=C78)C(N[C@@H](CCCCN)C(N[C@@H](CC9=CC=C(C=C9)O)C(N%10[C@@H](CCC%10)C(N[C@H]%11CC%12=CNC%13=CC=CC=C%12%13)=O)=O)=O)=O)=O)=O)NC3=O)C(N[C@@H](CC(O)=O)C(N%14[C@@H](CCC%14)C(N[C@@H](CCCCN)C(N[C@@H](C)C(N[C@@H](CO)C(N[C@@H](CCCCN)C(N[C@H]4CSSC[C@@H](C(N[C@@H](CCCNC(N)=N)C(N[C@@H](CC%15=CC=C(C=C%15)O)C(N[C@@H](CCCCN)C(N[C@@H](CC(C)C)C(N[C@@H](CC%16=CC=CC=C%16)C(O)=O)=O)=O)=O)=O)=O)NC%11=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)[C@H](C)N

• Molecular Weight:

  4058.64

• References & Citations:

  [1]Gonçalves TC, et al. Evaluation of the Spider (Phlogiellus genus) Phlotoxin 1 and Synthetic Variants as Antinociceptive Drug Candidates. Toxins (Basel). 2019 Aug 22;11(9):484.|[2]Nicolas S, et al. Chemical Synthesis, Proper Folding, Nav Channel Selectivity Profile and Analgesic Properties of the Spider Peptide Phlotoxin 1. Toxins (Basel). 2019 Jun 21;11(6):367.

• Shipping Conditions:

  Room temperature

• Clinical Information:

  No Development Reported