Catestatin (rat)

• Description:

  Catestatin (rat) (Rat chromogranin A367–387) is a potent, reversible, noncompetitive, and noncooperative nicotinic cholinergic antagonist derived from chromogranin A (A367-387) . Catestatin (rat) inhibits norepinephrine release in rat PC12 pheochromocytoma cells (IC50 = 1.2 μM), and blocks desensitization of norepinephrine release (IC50 = 0.62 μM) . Catestatin (rat) exerts antiadrenergic effects through the endothelial PI3K-AKT-eNOS pathway in rat papillary muscles and isolated cardiomyocytes. Catestatin (rat) maintains mitochondrial membrane potential in I/R cardiomyocytes and increases phosphorylation of AKT at S473, GSK3β at S9, PLB at T17, and eNOS at S1179. Catestatin (rat) reverses desensitization of 22Na+ uptake. Catestatin (rat) can be used for the study of nicotinic cholinergic receptor regulation and catecholamine release control mechanisms[1][2].

• Product Name Alternative:

  Rat chromogranin A367–387

• UNSPSC:

  12352209

• Target:

  Akt; nAChR

• Related Pathways:

  Membrane Transporter/Ion Channel; Neuronal Signaling; PI3K/Akt/mTOR

• Applications:

  Neuroscience-Neuromodulation

• Field of Research:

  Cardiovascular Disease

• Smiles:

  O=C (N[C@@H] (CO) C (N[C@@H] (CCSC) C (N[C@@H] (CCCCN) C (N[C@@H] (CC (C) C) C (N[C@@H] (CO) C (N[C@@H] (CC1=CC=CC=C1) C (N[C@@H] (CCCNC (N) =N) C (N[C@@H] (C) C (N[C@@H] (CCCNC (N) =N) C (N[C@@H] (C) C (N[C@@H] (CC2=CC=C (C=C2) O) C (NCC (N[C@@H] (CC3=CC=CC=C3) C (N[C@@H] (CCCNC (N) =N) C (N[C@@H] (CC (O) =O) C (N4[C@@H] (CCC4) C (NCC (N5[C@@H] (CCC5) C (N[C@@H] (CCC (N) =O) C (N[C@@H] (CC (C) C) C (O) =O) =O) =O) =O) =O) =O) =O) =O) =O) =O) =O) =O) =O) =O) =O) =O) =O) =O) =O) =O) [C@H] (CCCNC (N) =N) N

• Molecular Formula:

  C109H173N35O28S

• Molecular Weight:

  2453.82

• References & Citations:

  [1]Mahata SK, et al. Desensitization of catecholamine release. The novel catecholamine release-inhibitory peptide catestatin (chromogranin a344-364) acts at the receptor to prevent nicotinic cholinergic tolerance. J Biol Chem. 1999 Jan 29;274 (5) :2920-8. |[2]Mahata SK, et al. Chromogranin A and its fragments in cardiovascular, immunometabolic, and cancer regulation. Ann N Y Acad Sci. 2019 Nov;1455 (1) :34-58.

• Shipping Conditions:

  Room temperature

• Scientific Category:

  Peptides

• Clinical Information:

  No Development Reported