Catestatin

• Description:

  Catestatin is a 21-amino acid residue, cationic and hydrophobic peptide. Catestatin is an endogenous peptide that regulates cardiac function and blood pressure[1]. Catestatin is a non-competitive nicotinic antagonist acting through nicotinic acetylcholine receptors (nAChRs) to inhibit catecholamine release[2].

• Product Name Alternative:

  Catestatin (cattle)

• UNSPSC:

  12352209

• Target:

  NAChR

• Type:

  Peptides

• Related Pathways:

  Membrane Transporter/Ion Channel; Neuronal Signaling

• Applications:

  Neuroscience-Neuromodulation

• Field of Research:

  Cardiovascular Disease

• Assay Protocol:

  https://www.medchemexpress.com/catestatin.html

• Purity:

  98.17

• Solubility:

  H2O : ≥ 100 mg/mL

• Smiles:

  O=C (N[C@@H] (CO) C (N[C@@H] (CCSC) C (N[C@@H] (CCCNC (N) =N) C (N[C@@H] (CC (C) C) C (N[C@@H] (CO) C (N[C@@H] (CC1=CC=CC=C1) C (N[C@@H] (CCCNC (N) =N) C (N[C@@H] (C) C (N[C@@H] (CCCNC (N) =N) C (NCC (N[C@@H] (CC2=CC=C (C=C2) O) C (NCC (N[C@@H] (CC3=CC=CC=C3) C (N[C@@H] (CCCNC (N) =N) C (NCC (N4[C@@H] (CCC4) C (NCC (N[C@@H] (CC (C) C) C (N[C@@H] (CCC (N) =O) C (N[C@@H] (CC (C) C) C (O) =O) =O) =O) =O) =O) =O) =O) =O) =O) =O) =O) =O) =O) =O) =O) =O) =O) =O) =O) =O) [C@H] (CCCNC (N) =N) N

• Molecular Formula:

  C107H173N37O26S

• Molecular Weight:

  2425.82

• References & Citations:

  [1]Nitish R Mahapatra. Catestatin Is a Novel Endogenous Peptide That Regulates Cardiac Function and Blood Pressure. Cardiovasc Res. 2008 Dec 1;80 (3) :330-8.|[2]Sebastian Kraszewski, et al. A Molecular Dynamics Study of Catestatin Docked on Nicotinic Acetylcholine Receptors to Identify Amino Acids Potentially Involved in the Binding of Chromogranin A Fragments. Phys Chem Chem Phys. 2015 Jul 14;17 (26) :17454-60.

• Shipping Conditions:

  Blue Ice

• Storage Conditions:

  -80°C, 2 years; -20°C, 1 year (Powder, sealed storage, away from moisture and light)

• Scientific Category:

  Peptides

• Clinical Information:

  No Development Reported

• CAS Number:

  142211-96-9