NNC0165-1273 (TFA)

CAT: 0804-HY-P11291ASize: 1 EachDry Ice: NoHazardous: No
CAT#:0804-HY-P11291ASize:1 Each
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Description
NNC0165-1273 (TFA) is the trifluoroacetic acid of NNC0165-1273 (HY-P11291) . NNC0165-1273 is an analog of gut hormone peptide YY (PYY3-36) . NNC0165-1273 has a superior affinity for Y2 receptor over Y1, Y4, and Y5 receptor. NNC0165-1273 has a potent anorectic effect and significantly reduces nighttime and ghrelin-induced food intake by producing early satiety. NNC0165-1273 inhibits ghrelin-induced cFos expression in NPY/AgRP neurons. NNC0165-1273 can be used for antiobesity therapies research[1].
UNSPSC
12352209
Target
Neuropeptide Y Receptor
Related Pathways
GPCR/G Protein; Neuronal Signaling
Field of Research
Metabolic Disease
Purity
97.79
Smiles
NC(NCCC[C@@H](CC(N[C@@H](CC1=CC=C(C=C1)O)C(N)=O)=O)NC([C@H](CCC(N)=O)NC([C@H](CCCNC(N)=N)NC([C@H]([C@H](O)C)NC([C@H](C(C)C)NC([C@H](CC2=CNC3=CC=CC=C32)NC([C@H](CC(N)=O)NC([C@H](CC(C)C)NC([C@H](CC4=CC=C(C=C4)O)NC([C@H](CC5=CNC=N5)NC([C@H](CCCNC(N)=N)NC([C@H](CC(C)C)NC([C@H](CO)NC([C@H](C)NC([C@H](CC6=CC=C(C=C6)O)NC([C@H](CC7=CC=C(C=C7)O)NC([C@H](CCCNC(N)=N)NC([C@H](CC(N)=O)NC([C@H](CC(C)C)NC([C@H](CCC(O)=O)NC([C@H](CCC(O)=O)NC([C@@H]8CCCN8C([C@H](CO)NC([C@H](C)NC([C@H](CC(O)=O)NC([C@H](CCC(O)=O)NC(CNC([C@@H]9CCCN9C([C@H](C)NC([C@H](CCC(O)=O)NC([C@@H]%10CCCN%10C([C@H](CCCCN)NC([C@H]([C@@H](C)CC)N)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=N.OC(C(F)(F)F)=O.[x]
Molecular Formula
C186H280N54O54·xC2HF3O2
Molecular Weight
4136.54 (free base)
References & Citations
[1]Jones ES, et al. Modified Peptide YY Molecule Attenuates the Activity of NPY/AgRP Neurons and Reduces Food Intake in Male Mice. Endocrinology. 2019 Nov 1;160 (11) :2737-2747.
Shipping Conditions
Blue Ice
Storage Conditions
-80°C, 2 years; -20°C, 1 year (Powder, sealed storage, away from moisture)
Scientific Category
Peptides
Clinical Information
No Development Reported

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