Cys-PKHB1

CAT: 0804-HY-P11205Size: 1 EachDry Ice: NoHazardous: No
CAT#:0804-HY-P11205Size:1 Each
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Description
Cys-PKHB1 (Cys-txCD47) is a peptide conjugated to PKHB1, a CD47 agonist peptide and a thrombospondin-1 peptide mimic with antitumor effects. PKHB1 induces mitochondrial alterations, ROS generation, intracellular Ca+ accumulation, and calcium-dependent cell death in breast cancer cells. PKHB1 induces immune system activation in breast cancer cells through immunogenic cell death[1][2].
CAS Number
[2378833-51-1]
Product Name Alternative
Cys-txCD47
UNSPSC
12352209
Target
CD47; Reactive Oxygen Species (ROS) ; Thrombopoietin Receptor
Related Pathways
Immunology/Inflammation; Metabolic Enzyme/Protease; NF-κB
Applications
COVID-19-immunoregulation
Field of Research
Cancer; Inflammation/Immunology
Smiles
NCCCC[C@H](C(O)=O)NC([C@H](CCCCN)NC([C@@H](NC([C@H](CCSC)NC([C@H](C(C)C)NC([C@H](C(C)C)NC([C@@H](NC([C@@H](NC([C@H](CCCNC(N)=N)NC([C@@H](CCCCN)NC([C@@H](N)CS)=O)=O)=O)CC1=CC=CC=C1)=O)CC2=CC=C(C=C2)O)=O)=O)=O)=O)CC3=CNC4=CC=CC=C34)=O)=O
Molecular Formula
C71H110N18O13S2
Molecular Weight
1487.88
References & Citations
[1]Mohanty A, et al. Protein-Caged Nanoparticles: A Promising Nanomedicine Against Cancer. Chonnam Med J. 2023 Jan;59 (1) :1-12.|[2]Calvillo-Rodríguez KM, et al. PKHB1, a thrombospondin-1 peptide mimic, induces anti-tumor effect through immunogenic cell death induction in breast cancer cells. Oncoimmunology. 2022 Apr 4;11 (1) :2054305.
Shipping Conditions
Room temperature
Scientific Category
Peptides
Clinical Information
No Development Reported

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