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DHSO rabbit pAb

CAT: 0855-ES16949-01Size: 50 µLDry Ice: NoHazardous: No
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CAT#:0855-ES16949-01Size:50 µL
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Background
Sorbitol dehydrogenase (SORD; EC 1.1.1.14) catalyzes the interconversion of polyols and their corresponding ketoses, and together with aldose reductase (ALDR1; MIM 103880), makes up the sorbitol pathway that is believed to play an important role in the development of diabetic complications (summarized by Carr and Markham, 1995 [PubMed 8535074]) . The first reaction of the pathway (also called the polyol pathway) is the reduction of glucose to sorbitol by ALDR1 with NADPH as the cofactor. SORD then oxidizes the sorbitol to fructose using NAD (+) cofactor.[supplied by OMIM, Jul 2010]
Description
Sorbitol dehydrogenase (SORD; EC 1. 1. 1. 14) catalyzes the interconversion of polyols and their corresponding ketoses, and together with aldose reductase (ALDR1; MIM 103880), makes up the sorbitol pathway that is believed to play an important role in the development of diabetic complications (summarized by Carr and Markham, 1995 [PubMed 8535074]). The first reaction of the pathway (also called the polyol pathway) is the reduction of glucose to sorbitol by ALDR1 with NADPH as the cofactor. SORD then oxidizes the sorbitol to fructose using NAD (+) cofactor. [supplied by OMIM, Jul 2010],
UniProt
Q00796
Swiss Prot
Q00796
Reactivity
Human; Mouse; Rat
Immunogen
Synthesized peptide derived from human DHSO
Target
DHSO
Clonality
Polyclonal
Source
Rabbit
Applications
WB; IP
Concentration
1 mg/ml
Dilution
WB 1:500-2000 IP 1:200
Buffer
-20°C/1 year
Storage Conditions
-20°C/1 year
Fragment
IgG
Subcellular Location
Mitochondrion membrane ; Peripheral membrane protein . Cell projection, cilium, flagellum . Associated with mitochondria of the midpiece and near the plasma membrane in the principal piece of the flagellum. Also found in the epididymosome, secreted by the epididymal epithelium and that transfers proteins from the epididymal fluid to the sperm surface. .
Gene ID (Human)
6652

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