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Calcimycin (hemicalcium hemimagnesium)

CAT: 0804-HY-N6687CSize: 1 EachDry Ice: NoHazardous: No
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CAT#:0804-HY-N6687CSize:1 Each
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Description
Calcimycin (A-23187) hemicalcium hemimagnesium is an antibiotic and a unique divalent cation ionophore (like calcium and magnesium) . Calcimycin hemicalcium hemimagnesium induces Ca2+-dependent cell death by increasing intracellular calcium concentration. Calcimycin hemicalcium hemimagnesium inhibits the growth of Gram-positive bacteria and some fungi. Calcimycin hemicalcium hemimagnesium also inhibits the activity of ATPase and uncouples oxidative phosphorylation (OXPHOS) of mammalian cells. Calcimycin hemicalcium hemimagnesium induces apoptosis and autophagy[1][2][3][4][5].
Product Name Alternative
A-23187 (hemicalcium hemimagnesium) ; Antibiotic A-23187 (hemicalcium hemimagnesium)
UNSPSC
12352005
Target
Antibiotic; Apoptosis; Autophagy; Bacterial; Fungal; Oxidative Phosphorylation
Related Pathways
Anti-infection; Apoptosis; Autophagy; Metabolic Enzyme/Protease
Applications
COVID-19-immunoregulation
Field of Research
Cancer; Infection
Smiles
O=C(C1=C2N=C(C[C@H]3O[C@]4(O[C@H]([C@H](C)C(C5=CC=CN5)=O)[C@H](C)C[C@H]4C)CC[C@H]3C)OC2=CC=C1NC)[O-].[Ca+2].[Mg+2].[0.25].[0.25]
Molecular Formula
C29H37N3O6.1/4Ca.1/4Me
Molecular Weight
555.59
References & Citations
[1]Wu Q, et al. Characterization of the biosynthesis gene cluster for the pyrrole polyether antibiotic calcimycin (A23187) in Streptomyces chartreusis NRRL 3882. Antimicrob Agents Chemother. 2011 Mar;55 (3) :974-82. |[2]Elliott JI, et al. IKCa1 activity is required for cell shrinkage, phosphatidylserine translocation and death in Tlymphocyte apoptosis. EMBO Rep. 2003 Feb;4 (2) :189-94.|[3]Engedal N, et al. Modulation of intracellular calcium homeostasis blocks autophagosome formation. Autophagy. 2013 Oct;9 (10) :1475-90.|[4]Mawatwal S, et al. Calcimycin mediates mycobacterial killing by inducing intracellular calcium-regulated autophagy in a P2RX7 dependent manner. Biochim Biophys Acta Gen Subj. 2017 Dec;1861 (12) :3190-3200.|[5]Wang JP, et al. Effect of norathyriol, isolated from Tripterospermum lanceolatum, on A23187-induced pleurisy and analgesia in mice. Naunyn Schmiedebergs Arch Pharmacol. 1994 Jul;350 (1) :90-5.
Shipping Conditions
Room temperature
Scientific Category
Natural Products
Clinical Information
No Development Reported

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