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Proglumide (hemicalcium)

CAT: 0804-HY-103354ASize: 1 EachDry Ice: NoHazardous: No
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Description
Proglumide hemicalcium is a nonpeptide and orally active cholecystokinin (CCK) -A/B receptors antagonist. Proglumide hemicalcium selective blocks CCK’s effects in the central nervous system (CNS) . Proglumide hemicalcium has ability to inhibit gastric secretion and to protect the gastroduodenal mucosa. Proglumide hemicalcium also has antiepileptic and antioxidant activities[1][2][3][4][5].
CAS Number
85068-56-0
UNSPSC
12352005
Target
Cholecystokinin Receptor
Type
Reference compound
Related Pathways
GPCR/G Protein; Neuronal Signaling
Applications
Metabolism-protein/nucleotide metabolism
Field of Research
Cancer; Endocrinology; Neurological Disease
Assay Protocol
https://www.medchemexpress.com/proglumide-hemicalcium.html
Solubility
10 mM in DMSO
Smiles
O=C([O-])CCC(NC(C1=CC=CC=C1)=O)C(N(CCC)CCC)=O.[Ca+2].[1/2]
Molecular Formula
C18H26N2O4.1/2Ca
Molecular Weight
353.44
References & Citations
[1]Ahmad M, et al. The effects of quinacrine, proglumide, and pentoxifylline on seizure activity, cognitive deficit, and oxidative stress in rat lithium-pilocarpine model of status epilepticus. Oxid Med Cell Longev. 2014;2014:630509.|[2]Iwamoto Y, et al. In vitro and in vivo effect of proglumide on cholecystokinin-stimulated amylase release in mouse pancreatic acini. Gastroenterol Jpn. 1984 Feb;19 (1) :53-8.|[3]González-Puga C, et al. Selective CCK-A but not CCK-B receptor antagonists inhibit HT-29 cell proliferation: synergism with pharmacological levels of melatonin. J Pineal Res. 2005 Oct;39 (3) :243-50.|[4]Bunney BS, et al. Further studies on the specificity of proglumide as a selective cholecystokinin antagonist in the central nervous system. Ann N Y Acad Sci. 1985;448:345-51.|[5]Tariq M, et al. Gastric and duodenal antiulcer and cytoprotective effects of proglumide in rats. J Pharmacol Exp Ther. 1987 May;241 (2) :602-7.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
Launched

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