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Calcimycin hemimagnesium

CAT: 0931-T75656-01Size: 5 mgDry Ice: NoHazardous: No
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CAT#:0931-T75656-01Size:5 mg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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CAS Number
72124-77-7
Target
Autophagy, Apoptosis, OXPHOS, Others, Antifungal, Antibacterial
Related Pathways
Autophagy, Microbiology/Virology, Others, Apoptosis
Bioactivity
Calcimycin (A-23187) hemimagnesium, an antibiotic and divalent cation ionophore (such as calcium and magnesium), serves various biological roles. It triggers Ca2+-dependent cell death by elevating intracellular calcium levels and suppresses the growth of Gram-positive bacteria and certain fungi. Additionally, this compound hinders ATPase activity and uncouples oxidative phosphorylation (OXPHOS) in mammalian cells, ultimately leading to apoptosis [1] [2] [3] [4].
Smiles
O=C1[O-][Mg+2]234([N]=5C=6C(C(=O)[O-]2)=C(NC)C=CC6OC5CC7OC8(OC(C(C)C(=O3)C9=CC=CN9)C(C)CC8C)CCC7C)[N]=%10C=%11C1=C(NC)C=CC%11OC%10CC%12OC%13(OC(C(C)C(=O4)C%14=CC=CN%14)C(C)CC%13C)CCC%12C
Molecular Formula
C58H72MgN6O12
Molecular Weight
1069.53
Shipping Conditions
Ice Packs
Storage Temperature
-20°C

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