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Atorvastatin hemicalcium

CAT: 0013-GTR19163801-01Size: 1 gDry Ice: NoHazardous: No
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CAT#:0013-GTR19163801-01Size:1 g
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Description
A competitive inhibitor of HMG-CoA reductase (HMGCR) that acts as a lipid-lowering agent for prevention of events associated with cardiovascular disease.Dyslipidemia Approved (In Vitro) :Atorvastatin treatment decreases apoptosis of myocardial cells by down-regulating GRP78, caspase-12 and CHOP expression in myocardial cells after myocardial infarction, and the endoplasmic reticulum (ER) stress is activated in response to heart failure and angiotensin II (Ang II) stimulation. (In Vivo) :Atorvastatin (20-30 mg/kg; oral gavage; once a day; for 28 days; ApoE / mice) treatment significantly reduces endoplasmic reticulum (ER) stress signaling proteins, the number of apoptotic cells, and the activation of Caspase12 and Bax in the Ang II-induced ApoE-/- mice. Proinflammatory cytokines such as IL-6, IL-8, IL-1β are all remarkably inhibited after Atorvastatin treatment.
CAS Number
134523-03-8
Product Name Alternative
Atorvastatin hemicalcium
Field of Research
Pharmacology & Drug Discovery
Purity
>98% (HPLC)
Solubility
10 mM in DMSO
Smiles
CC (C) C1=C (C (=C (N1CC[C@H] (C[C@H] (CC (=O) [O-]) O) O) C2=CC=C (C=C2) F) C3=CC=CC=C3) C (=O) NC4=CC=CC=C4.CC (C) C1=C (C (=C (N1CC[C@H] (C[C@H] (CC (=O) [O-]) O) O) C2=CC=C (C=C2) F) C3=CC=CC=C3) C (=O) NC4=CC=CC=C4.[Ca+2]
Molecular Formula
C33H34FN2O5-
Molecular Weight
557.6324
Storage Conditions
Storage temperature: -20°C. Stability: ≥ 2 years
Notes
For research use only.
Other Product Names
1H-Pyrrole-1-heptanoic acid, 2- (4-fluorophenyl) -β, δ-dihydroxy-5- (1-methylethyl) -3-phenyl-4-[ (phenylamino) carbonyl]-, calcium salt (2:1), (βR, δR) -

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