(-) -Securinine (nitrate)

• Description :

  (-) -Securinine (nitrate) is plant-derived alkaloid and also a GABAA receptor antagonist[1][2].

• UNSPSC :

  12352005

• Target :

  GABA Receptor

• Related Pathways :

  Membrane Transporter/Ion Channel; Neuronal Signaling

• Field of Research :

  Cancer; Neurological Disease

• Smiles :

  O=C(O1)C=C2[C@@]13[C@](CCCC4)([H])N4[C@](C3)([H])C=C2.O[N+]([O-])=O

• Molecular Formula :

  C13H16N2O5

• Molecular Weight :

  280.28

• References & Citations :

  [1]Stefanowicz-Hajduk J, et al. Securinine from Phyllanthus glaucus Induces Cell Cycle Arrest and Apoptosis in Human Cervical Cancer HeLa Cells. PLoS One. 2016 Oct 28;11 (10) :e0165372. |[2]Kalpana Gupta, et al. Securinine, a Myeloid Differentiation Agent with Therapeutic Potential for AML. PLoS One. 2011; 6 (6) : e21203.

• Shipping Conditions :

  Room temperature

• Scientific Category :

  Reference compound1

• Clinical Information :

  No Development Reported

• CAS Number :

  [7104-26-9]