Sempervirine (nitrate)

• Description :

  Sempervirine is an alkaloid derived from Gelsemium elegans Benth.. Sempervirine inhibits the proliferation of hepatocellular carcinoma (HCC) cells and induces apoptosis by regulating Wnt/β-catenin pathway[1].

• UNSPSC :

  12352005

• Target :

  Wnt; β-catenin

• Type :

  Natural Products

• Related Pathways :

  Stem Cell/Wnt

• Applications :

  Cancer-programmed cell death

• Field of Research :

  Cancer

• Assay Protocol :

  https://www.medchemexpress.com/sempervirine-nitrate.html

• Solubility :

  10 mM in DMSO

• Smiles :

  O=[N+]([O-])[O-].C12=C(NC3=C2C=C[N+]4=C3C=C(CCCC5)C5=C4)C=CC=C1

• Molecular Formula :

  C19H17N3O3

• Molecular Weight :

  335.36

• References & Citations :

  [1]Yue R, et al. Sempervirine Inhibits Proliferation and Promotes Apoptosis by Regulating Wnt/β-Catenin Pathway in Human Hepatocellular Carcinoma. Front Pharmacol. 2021 Dec 7;12:806091.

• Shipping Conditions :

  Room temperature

• Scientific Category :

  Natural Products

• Clinical Information :

  No Development Reported

• CAS Number :

  [17994-15-9]