Sempervirine (nitrate)

• CAS Number:

  17994-15-9

• UNSPSC Description:

  Sempervirine is an alkaloid derived from Gelsemium elegans Benth.. Sempervirine inhibits the proliferation of hepatocellular carcinoma (HCC) cells and induces apoptosis by regulating Wnt/β-catenin pathway[1].

• Target Antigen:

  Wnt; β-catenin

• Type:

  Natural Products

• Related Pathways:

  Stem Cell/Wnt

• Applications:

  Cancer-programmed cell death

• Field of Research:

  Cancer

• Assay Protocol:

  https://www.medchemexpress.com/sempervirine-nitrate.html

• Solubility:

  10 mM in DMSO

• Smiles:

  O=[N+]([O-])[O-].C12=C(NC3=C2C=C[N+]4=C3C=C(CCCC5)C5=C4)C=CC=C1

• Molecular Weight:

  335.36

• References & Citations:

  [1]Yue R, et al. Sempervirine Inhibits Proliferation and Promotes Apoptosis by Regulating Wnt/β-Catenin Pathway in Human Hepatocellular Carcinoma. Front Pharmacol. 2021 Dec 7;12:806091.

• Shipping Conditions:

  Room temperature

• Clinical Information:

  No Development Reported