Sempervirine (nitrate)

Sempervirine (nitrate)

• CAS Number: 17994-15-9
• UNSPSC Description: Sempervirine is an alkaloid derived from Gelsemium elegans Benth.. Sempervirine inhibits the proliferation of hepatocellular carcinoma (HCC) cells and induces apoptosis by regulating Wnt/β-catenin pathway[1].
• Target Antigen: Wnt; β-catenin
• Type: Natural Products
• Related Pathways: Stem Cell/Wnt
• Applications: Cancer-programmed cell death
• Field of Research: Cancer
• Assay Protocol: https://www.medchemexpress.com/sempervirine-nitrate.html
• Solubility: 10 mM in DMSO
• Smiles: O=[N+]([O-])[O-].C12=C(NC3=C2C=C[N+]4=C3C=C(CCCC5)C5=C4)C=CC=C1
• Molecular Weight: 335.36
• References & Citations: [1]Yue R, et al. Sempervirine Inhibits Proliferation and Promotes Apoptosis by Regulating Wnt/β-Catenin Pathway in Human Hepatocellular Carcinoma. Front Pharmacol. 2021 Dec 7;12:806091.
• Shipping Conditions: Room temperature
• Clinical Information: No Development Reported