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Naphazoline (nitrate)

CAT: 0804-HY-111326A-01Size: 1 gDry Ice: NoHazardous: No
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CAT#:0804-HY-111326A-01Size:1 g
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Description
Naphazoline (Naphthazoline) nitrate is an α-adrenergic receptor agonist. Naphazoline nitrate reduces vascular hyperpermeability and promotes vasoconstriction. Naphazoline nitrate reduces the levels of inflammatory factors (TNF-α, IL-1β and IL-6), cytokines (IFN-γ and IL-4), IgE, GMCSF, and NGF. Naphazoline nitrate can be used for non-bacterial conjunctivitis research[1][2].
CAS Number
5144-52-5
Product Name Alternative
Naphthazoline (nitrate)
UNSPSC
12352005
Hazard Statement
H302
Target
Adrenergic Receptor; Interleukin Related; TNF Receptor; VEGFR
Type
Reference compound
Related Pathways
Apoptosis; GPCR/G Protein; Immunology/Inflammation; Neuronal Signaling; Protein Tyrosine Kinase/RTK
Applications
COVID-19-immunoregulation
Field of Research
Inflammation/Immunology; Cardiovascular Disease; Cancer
Assay Protocol
https://www.medchemexpress.com/naphazoline-nitrate.html
Concentration
10mM
Purity
99.12
Solubility
DMSO : 100 mg/mL (ultrasonic)
Smiles
O[N+]([O-])=O.C1(CC2=C3C=CC=CC3=CC=C2)=NCCN1
Molecular Formula
C14H15N3O3
Molecular Weight
273.29
Precautions
H302
References & Citations
[1]Quan L, et, al. Treatment with olopatadine and naphazoline hydrochloride reduces allergic conjunctivitis in mice through alterations in inflammation, NGF and VEGF. Mol Med Rep. 2016 Apr;13 (4) :3319-25.|[2]Yamaguchi I, et, al. Central and peripheral adrenergic mechanisms regulating gastric secretion in the rat. J Pharmacol Exp Ther. 1977 Oct;203 (1) :125-31.
Shipping Conditions
Room Temperature
Storage Conditions
4°C (Powder, sealed storage, away from moisture)
Scientific Category
Reference compound1
Clinical Information
Launched
Isoform
IL-1; IL-4; IL-6; TNFRSF5/CD40

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