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Oxiconazole nitrate

CAT: 0804-HY-B1324-01Size: 5 mgDry Ice: NoHazardous: No
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CAT#:0804-HY-B1324-01Size:5 mg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
Oxiconazole (Ro 13-8996) nitrate is a broad spectrum anti-fungal agent which can inhibit the growth of Candida, Aspergillus and Trichophyton. Oxiconazole nitrate is also a highly efficacious activator of CYP3A4 transactivation, which could be antagonized by Rifampicin in a competitive manner. Oxiconazole nitrate exhibits inhibitory effect against colorectal cancer (CRC) via peroxiredoxin-2 (PRDX2) -mediated autophagy arrest[1][2][3].
CAS Number
64211-46-7
Product Name Alternative
Ro 13-8996
UNSPSC
12352005
Hazard Statement
H272, H315, H319
Target
Antibiotic; Cytochrome P450; Fungal
Type
Reference compound
Related Pathways
Anti-infection; Metabolic Enzyme/Protease
Applications
COVID-19-immunoregulation
Field of Research
Cancer; Infection
Assay Protocol
https://www.medchemexpress.com/Oxiconazole_nitrate.html
Purity
98.0
Solubility
DMSO : ≥ 100 mg/mL
Smiles
[O-][N+](O)=O.ClC1=CC=C(/C(CN2C=CN=C2)=N/OCC3=CC=C(Cl)C=C3Cl)C(Cl)=C1
Molecular Formula
C18H14Cl4N4O4
Molecular Weight
492.14
Precautions
H272, H315, H319
References & Citations
[1]Rossello A, et al. Synthesis, antifungal activity, and molecular modeling studies of new inverted oxime ethers of oxiconazole. J Med Chem. 2002 Oct 24;45 (22) :4903-12.|[2]Svecova L, et al. Azole antimycotics differentially affect rifampicin-induced pregnane X receptor-mediated CYP3A4 gene expression. Drug Metab Dispos. 2008 Feb;36 (2) :339-48.|[3]Shi J, et al. Repurposing Oxiconazole against Colorectal Cancer via PRDX2-mediated Autophagy Arrest. Int J Biol Sci. 2022 May 21;18 (9) :3747-3761.
Shipping Conditions
Room Temperature
Storage Conditions
4°C (Powder, sealed storage, away from moisture)
Scientific Category
Reference compound1
Clinical Information
Launched
Isoform
CYP3

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