N-Acetoxy-IQ

CAT: 0804-HY-N15366Size: 1 EachDry Ice: NoHazardous: No
CAT#:0804-HY-N15366Size:1 Each
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Description
N-Acetoxy-IQ is a DNA alkylating agent that can covalently bind to DNA, especially guanine residues. N-Acetoxy-IQ exerts mutagenic and carcinogenic activities by forming DNA adducts. N-Acetoxy-IQ is promising for research of cancers[1][2][3].
CAS Number
[115722-78-6]
UNSPSC
12352005
Target
DNA Alkylator/Crosslinker
Related Pathways
Cell Cycle/DNA Damage
Field of Research
Cancer
Smiles
O=C(C)O/N=C1NC2=C(N/1C)C=CC3=NC=CC=C23
Molecular Formula
C13H12N4O2
Molecular Weight
256.26
References & Citations
[1]Schut HA, et al. Similar patterns of DNA adduct formation of 2-amino-3-methylimidazo [4,5-f]quinoline in the Fischer 344 rat, CDF1 mouse, cynomolgus monkey and Salmonella typhimurium. Carcinogenesis. 1991 May;12 (5) :931-4.|[2]Turesky RJ, et al. Formation and persistence of DNA adducts of 2-amino-3-methylimidazo[4,5-f]quinoline in the rat and nonhuman primates. Mutat Res. 1997 May 12;376 (1-2) :235-41.|[3]Turesky RJ, et al. DNA adduct formation of the food carcinogen 2-amino-3-methylimidazo[4,5- f]quinoline at the C-8 and N2 atoms of guanine. Chem Res Toxicol. 1994 Nov-Dec;7 (6) :752-61.
Shipping Conditions
Room temperature
Scientific Category
Natural Products
Clinical Information
No Development Reported

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