N-Acetoxy-IQ

• Description:

  N-Acetoxy-IQ is a DNA alkylating agent that can covalently bind to DNA, especially guanine residues. N-Acetoxy-IQ exerts mutagenic and carcinogenic activities by forming DNA adducts. N-Acetoxy-IQ is promising for research of cancers[1][2][3].

• UNSPSC:

  12352005

• Target:

  DNA Alkylator/Crosslinker

• Related Pathways:

  Cell Cycle/DNA Damage

• Field of Research:

  Cancer

• Smiles:

  O=C (C) O/N=C1NC2=C (N/1C) C=CC3=NC=CC=C23

• Molecular Formula:

  C13H12N4O2

• Molecular Weight:

  256.26

• References & Citations:

  [1]Schut HA, et al. Similar patterns of DNA adduct formation of 2-amino-3-methylimidazo [4,5-f]quinoline in the Fischer 344 rat, CDF1 mouse, cynomolgus monkey and Salmonella typhimurium. Carcinogenesis. 1991 May;12 (5) :931-4.|[2]Turesky RJ, et al. Formation and persistence of DNA adducts of 2-amino-3-methylimidazo[4,5-f]quinoline in the rat and nonhuman primates. Mutat Res. 1997 May 12;376 (1-2) :235-41.|[3]Turesky RJ, et al. DNA adduct formation of the food carcinogen 2-amino-3-methylimidazo[4,5- f]quinoline at the C-8 and N2 atoms of guanine. Chem Res Toxicol. 1994 Nov-Dec;7 (6) :752-61.

• Shipping Conditions:

  Room temperature

• Scientific Category:

  Natural Products

• Clinical Information:

  No Development Reported

• CAS Number:

  115722-78-6