IQ-3

• Description:

  IQ-3 is a specific inhibitor of the c-Jun N-terminal kinase (JNK) family, with preference for JNK3. IQ-3 exhibits Kd values of 0.24 μM, 0.29 μM and 0.066 μM for JNK1, JNK2 and JNK3, respectively[1].

• UNSPSC:

  12352005

• Hazard Statement:

  H302, H315, H319, H335

• Target:

  JNK

• Type:

  Reference compound

• Related Pathways:

  MAPK/ERK Pathway

• Applications:

  COVID-19-immunoregulation

• Field of Research:

  Inflammation/Immunology

• Assay Protocol:

  https://www.medchemexpress.com/iq-3.html

• Purity:

  99.38

• Solubility:

  DMSO : 25 mg/mL (ultrasonic)

• Smiles:

  O=C (O/N=C1C2=C (C3=NC4=CC=CC=C4N=C3\1) C=CC=C2) C5=CC=CO5

• Molecular Formula:

  C20H11N3O3

• Molecular Weight:

  341.32

• Precautions:

  H302, H315, H319, H335

• References & Citations:

  [1]Igor A Schepetkin, et al. Identification and characterization of a novel class of c-Jun N-terminal kinase inhibitors. Mol Pharmacol. 2012 Jun;81 (6) :832-45.

• Shipping Conditions:

  Blue Ice

• Storage Conditions:

  -20°C, 3 years (Powder)

• Scientific Category:

  Reference compound1

• Clinical Information:

  No Development Reported

• Isoform:

  JNK1; JNK2; JNK3

• CAS Number:

  312538-03-7