IQ-3

• Description :

  IQ-3 is a specific inhibitor of the c-Jun N-terminal kinase (JNK) family, with preference for JNK3. IQ-3 exhibits Kd values of 0.24 μM, 0.29 μM and 0.066 μM for JNK1, JNK2 and JNK3, respectively[1].

• UNSPSC :

  12352005

• Hazard Statement :

  H302, H315, H319, H335

• Target :

  JNK

• Type :

  Reference compound

• Related Pathways :

  MAPK/ERK Pathway

• Applications :

  COVID-19-immunoregulation

• Field of Research :

  Inflammation/Immunology

• Assay Protocol :

  https://www.medchemexpress.com/iq-3.html

• Purity :

  99.38

• Solubility :

  DMSO : 25 mg/mL (ultrasonic)

• Smiles :

  O=C(O/N=C1C2=C(C3=NC4=CC=CC=C4N=C3\1)C=CC=C2)C5=CC=CO5

• Molecular Formula :

  C20H11N3O3

• Molecular Weight :

  341.32

• Precautions :

  H302, H315, H319, H335

• References & Citations :

  [1]Igor A Schepetkin, et al. Identification and characterization of a novel class of c-Jun N-terminal kinase inhibitors. Mol Pharmacol. 2012 Jun;81 (6) :832-45.

• Shipping Conditions :

  Blue Ice

• Storage Conditions :

  -20°C, 3 years (Powder)

• Scientific Category :

  Reference compound1

• Clinical Information :

  No Development Reported

• Isoform :

  JNK1; JNK2; JNK3

• CAS Number :

  [312538-03-7]