IQ-1S

• Description:

  IQ-1S is a prospective inhibitor of NF-κB/activating protein 1 (AP-1) activity with an IC50 of 1.8 μM. IQ-1 has binding affinity (Kd values) in the nanomolar range for all three JNKs with Kds of 87 nM, 360 nM, and 390 nM for JNK3, JNK2, and JNK1, respectively.

• UNSPSC:

  12352005

• Target:

  JNK

• Type:

  Reference compound

• Related Pathways:

  MAPK/ERK Pathway

• Field of Research:

  Cancer; Inflammation/Immunology

• Assay Protocol:

  https://www.medchemexpress.com/iq-1s.html

• Smiles:

  [Na]O/N=C1C2=C(C3=NC4=CC=CC=C4N=C3\1)C=CC=C2

• Molecular Formula:

  C15H8N3NaO

• Molecular Weight:

  269.23

• References & Citations:

  [1]Schepetkin IA, et al. Identification and characterization of a novel class of c-Jun N-terminal kinase inhibitors. Mol Pharmacol. 2012 Jun;81 (6) :832-45.

• Shipping Conditions:

  Room temperature

• Scientific Category:

  Reference compound1

• Clinical Information:

  No Development Reported

• Isoform:

  JNK1; JNK2; JNK3

• CAS Number:

  [1421610-21-0]