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IQ-1S

CAT: 0804-HY-100233ASize: 1 EachDry Ice: NoHazardous: No
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CAT#:0804-HY-100233ASize:1 Each
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Description
IQ-1S is a prospective inhibitor of NF-κB/activating protein 1 (AP-1) activity with an IC50 of 1.8 μM. IQ-1 has binding affinity (Kd values) in the nanomolar range for all three JNKs with Kds of 87 nM, 360 nM, and 390 nM for JNK3, JNK2, and JNK1, respectively.
CAS Number
1421610-21-0
UNSPSC
12352005
Target
JNK
Type
Reference compound
Related Pathways
MAPK/ERK Pathway
Field of Research
Cancer; Inflammation/Immunology
Assay Protocol
https://www.medchemexpress.com/iq-1s.html
Smiles
[Na]O/N=C1C2=C(C3=NC4=CC=CC=C4N=C3\1)C=CC=C2
Molecular Formula
C15H8N3NaO
Molecular Weight
269.23
References & Citations
[1]Schepetkin IA, et al. Identification and characterization of a novel class of c-Jun N-terminal kinase inhibitors. Mol Pharmacol. 2012 Jun;81 (6) :832-45.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Isoform
JNK1; JNK2; JNK3

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452455-01IQ 1S
B1279-5IQ-1S
A16062-100IQ-1S 100mg
A16062-25IQ-1S 25mg
A16062-200IQ-1S 200mg
A16062-500IQ-1S 500mg
A16062-50IQ-1S 50mg

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