MO-2097

CAT: 0804-HY-N13009Size: 1 EachDry Ice: NoHazardous: No
CAT#:0804-HY-N13009Size:1 Each
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Description
MO-2097 is a RAF-1/HIF-1α inhibitor. MO-2097 induces RAF-1 destabilization, leading to a reduction in EMT-associated transcription factors and mesenchymal markers. MO-2097 inhibits HIF-1a protein expression mediated by hnRNPA2B1 under hypoxic and mimetic hypoxia. MO-2097 induces mitochondrial ROS, which leads to apoptosis in cells. MO-2097 effectively suppresses colorectal cancer metastasis by inhibiting the RAF/MEK/ERK signaling pathway. MO-2097 attenuates tumor growth in a xenograft HCT116 cell mouse model. MO-2097 can be used for the study of colorectal cancer[1][2].
CAS Number
[2744300-63-6]
UNSPSC
12352005
Target
Apoptosis; Caspase; ERK; HIF/HIF Prolyl-Hydroxylase; MEK; Raf; Reactive Oxygen Species (ROS)
Related Pathways
Apoptosis; Immunology/Inflammation; MAPK/ERK Pathway; Metabolic Enzyme/Protease; NF-κB; Stem Cell/Wnt
Applications
Cancer-Kinase/protease
Field of Research
Cancer
Smiles
OC1=CC(C2=CC3=C(C=C4OCC(C)=CCC4=C3)O2)=CC(O)=C1
Molecular Formula
C19H16O4
Molecular Weight
308.33
References & Citations
[1]Kim S, et al. MO-2097 inhibits EMT and angiogenesis in colorectal cancer by targeting RAF/MEK/ERK signaling. Sci Rep. 2025 Jul 1;15 (1) :21781.|[2]Han HJ, et al. HIF-1α inhibition by MO-2097, a novel chiral-free benzofuran targeting hnRNPA2B1. J Adv Res. 2024 Oct;64:67-81.
Shipping Conditions
Room temperature
Scientific Category
Natural Products
Clinical Information
No Development Reported

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