MO-I-1100

• Description:

  MO-I-1100 is an inhibitor of ASPH (Aspartyl- (Asparaginyl) -β-hydroxylase) enzymatic activity. MO-I-1100 suppresses HCC cell migration, invasion and anchorage independent growth. MO-I-1100 shows antitumor effects through inhibiting Notch signaling cascade in HCC[1].

• UNSPSC:

  12352005

• Target:

  Notch

• Type:

  Reference compound

• Related Pathways:

  Neuronal Signaling; Stem Cell/Wnt

• Applications:

  Cancer-programmed cell death

• Field of Research:

  Cancer

• Assay Protocol:

  https://www.medchemexpress.com/mo-i-1100.html

• Purity:

  99.76

• Solubility:

  DMSO : 15 mg/mL (ultrasonic; warming; heat to 60°C)

• Smiles:

  O=C1C(OS(CC2=CC=CC=C2)(=O)=O)=C(N)OC1C3=CC=C(Cl)C=C3

• Molecular Formula:

  C17H14ClNO5S

• Molecular Weight:

  379.81

• References & Citations:

  [1]Aihara A, et al. A cell-surface β-hydroxylase is a biomarker and therapeutic target for hepatocellular carcinoma. Hepatology. 2014 Oct;60 (4) :1302-13.

• Shipping Conditions:

  Room Temperature

• Storage Conditions:

  4°C (Powder, protect from light)

• Scientific Category:

  Reference compound1

• Clinical Information:

  No Development Reported

• CAS Number:

  [1585217-40-8]