MO-2097

• Target :

  ROS|||Apoptosis|||Caspase|||MEK|||ERK|||HIF/HIF Prolyl-Hydroxylase|||Raf

• Related Pathways :

  Immunology/Inflammation|||Metabolism|||Apoptosis|||Proteases/Proteasome|||Chromatin/Epigenetic|||MAPK

• Bioactivity :

  MO-2097 is an inhibitor of RAF-1 and HIF-1?. It destabilizes RAF-1, reducing EMT-related transcription factors and mesenchymal markers. MO-2097 suppresses HIF-1? protein expression under hypoxic or hypoxia-mimicking conditions via hnRNPA2B1. It induces mitochondrial ROS production, leading to cell apoptosis. By inhibiting the RAF/MEK/ERK signaling pathway, MO-2097 effectively prevents colorectal cancer metastasis. It also inhibits tumor growth in human colorectal cancer HCT116 cell xenograft mouse models. MO-2097 is applicable for colorectal cancer research.

• Smiles :

  OC=1C=C(O)C=C(C1)C=2OC=3C=C4OCC(=CCC4=CC3C2)C

• Molecular Formula :

  C19H16O4

• Molecular Weight :

  308.33

• Shipping Conditions :

  Cool pack

• Storage Temperature :

  -20°C

• CAS Number :

  2744300-63-6