(±) -10-Hydroxycamptothecin (Standard)

• Description:

  (±) -10-Hydroxycamptothecin (Standard) is the analytical standard of (±) -10-Hydroxycamptothecin. This product is intended for research and analytical applications. (±) -10-Hydroxycamptothecin is an indole alkaloid that inhibits the activity of topoisomerase I and has a broad spectrum of anticancer activity.

• UNSPSC:

  12352100

• Target:

  Reference Standards; Topoisomerase

• Related Pathways:

  Cell Cycle/DNA Damage; Others

• Field of Research:

  Cancer

• Smiles:

  O=C1C(O)(CC)C2=C(CO1)C(N3CC4=CC5=CC(O)=CC=C5N=C4C3=C2)=O

• Molecular Formula:

  C20H16N2O5

• Molecular Weight:

  364.35

• References & Citations:

  [1]Liu SY, et al. Interaction of several nucleoside triphosphate analogues and 10-hydroxycamptothecin with human DNA topoisomerases. Cancer Res. 1989 Mar 15;49 (6) :1366-70.|[2]Ping YH, et al. Anticancer effects of low-dose 10-hydroxycamptothecin in human colon cancer. Oncol Rep. 2006 May;15 (5) :1273-9.|[3]Fan J, et al. Detection of apoptosis exposed to 10-hydroxycamptothecin in T24 human urinary bladder cancer cells. Zhonghua Wai Ke Za Zhi. 1999 Jan;37 (1) :57-9.

• Shipping Conditions:

  Room temperature

• Scientific Category:

  Reference Standards

• CAS Number:

  [64439-81-2]