(±) -10-Hydroxycamptothecin

• Description :

  (±) -10-Hydroxycamptothecin is an indole alkaloid that inhibits the activity of topoisomerase I and has a broad spectrum of anticancer activity.

• Product Name Alternative :

  (±) -10-HCPT

• UNSPSC :

  12352005

• Hazard Statement :

  H301, H340

• Target :

  Topoisomerase

• Type :

  Natural Products

• Related Pathways :

  Cell Cycle/DNA Damage

• Applications :

  Cancer-programmed cell death

• Field of Research :

  Cancer

• Assay Protocol :

  https://www.medchemexpress.com/__plusmn__-10-Hydroxycamptothecin.html

• Purity :

  99.57

• Solubility :

  DMSO : 25 mg/mL (ultrasonic)

• Smiles :

  O=C1C(O)(CC)C2=C(CO1)C(N3CC4=CC5=CC(O)=CC=C5N=C4C3=C2)=O

• Molecular Formula :

  C20H16N2O5

• Molecular Weight :

  364.35

• Precautions :

  H301, H340

• References & Citations :

  [1]Liu SY, et al. Interaction of several nucleoside triphosphate analogues and 10-hydroxycamptothecin with human DNA topoisomerases. Cancer Res. 1989 Mar 15;49 (6) :1366-70.|[2]Ping YH, et al. Anticancer effects of low-dose 10-hydroxycamptothecin in human colon cancer. Oncol Rep. 2006 May;15 (5) :1273-9.|[3]Fan J, et al. Detection of apoptosis exposed to 10-hydroxycamptothecin in T24 human urinary bladder cancer cells. Zhonghua Wai Ke Za Zhi. 1999 Jan;37 (1) :57-9.

• Shipping Conditions :

  Room Temperature

• Storage Conditions :

  -20°C, 3 years; 4°C, 2 years (Powder)

• Scientific Category :

  Natural Products

• Clinical Information :

  No Development Reported

• Isoform :

  Topo I

• CAS Number :

  [64439-81-2]