(±) -10-Hydroxycamptothecin

CAT: 0804-HY-N0275-01Size: 5 mgDry Ice: NoHazardous: No
CAT#:0804-HY-N0275-01Size:5 mg
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Description
(±) -10-Hydroxycamptothecin is an indole alkaloid that inhibits the activity of topoisomerase I and has a broad spectrum of anticancer activity.
CAS Number
[64439-81-2]
Product Name Alternative
(±) -10-HCPT
UNSPSC
12352005
Hazard Statement
H301, H340
Target
Topoisomerase
Type
Natural Products
Related Pathways
Cell Cycle/DNA Damage
Applications
Cancer-programmed cell death
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/__plusmn__-10-Hydroxycamptothecin.html
Purity
99.57
Solubility
DMSO : 25 mg/mL (ultrasonic)
Smiles
O=C1C(O)(CC)C2=C(CO1)C(N3CC4=CC5=CC(O)=CC=C5N=C4C3=C2)=O
Molecular Formula
C20H16N2O5
Molecular Weight
364.35
Precautions
H301, H340
References & Citations
[1]Liu SY, et al. Interaction of several nucleoside triphosphate analogues and 10-hydroxycamptothecin with human DNA topoisomerases. Cancer Res. 1989 Mar 15;49 (6) :1366-70.|[2]Ping YH, et al. Anticancer effects of low-dose 10-hydroxycamptothecin in human colon cancer. Oncol Rep. 2006 May;15 (5) :1273-9.|[3]Fan J, et al. Detection of apoptosis exposed to 10-hydroxycamptothecin in T24 human urinary bladder cancer cells. Zhonghua Wai Ke Za Zhi. 1999 Jan;37 (1) :57-9.
Shipping Conditions
Room Temperature
Storage Conditions
-20°C, 3 years; 4°C, 2 years (Powder)
Scientific Category
Natural Products
Clinical Information
No Development Reported
Isoform
Topo I

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