(S) -10-Hydroxycamptothecin

• Description:

  (S) -10-Hydroxycamptothecin (10-HCPT;10-Hydroxycamptothecin) is a DNA topoisomerase I inhibitor of isolated from the Chinese plant Camptotheca accuminata. (S) -10-Hydroxycamptothecin exhibits a remarkable apoptosis-inducing effect. (S) -10-Hydroxycamptothecin has the potential for hepatoma, gastric carcinoma, colon cancer and leukaemia treatment[1][2][3][4].

• Product Name Alternative:

  10-HCPT; 10-Hydroxycamptothecin

• UNSPSC:

  12352005

• Hazard Statement:

  H302, H315, H319

• Target:

  Apoptosis; Topoisomerase

• Type:

  Natural Products

• Related Pathways:

  Apoptosis; Cell Cycle/DNA Damage

• Applications:

  Cancer-programmed cell death

• Field of Research:

  Cancer

• Assay Protocol:

  https://www.medchemexpress.com/_S_-10-Hydroxycamptothecin.html

• Purity:

  99.74

• Solubility:

  DMSO : 50 mg/mL (ultrasonic)

• Smiles:

  O=C1[C@](O)(CC)C2=C(CO1)C(N3CC4=CC5=CC(O)=CC=C5N=C4C3=C2)=O

• Molecular Formula:

  C20H16N2O5

• Molecular Weight:

  364.35

• Precautions:

  H302, H315, H319

• References & Citations:

  [1]Min Liu, et al. Intracellular delivery of 10-hydroxycamptothecin with targeted nanostructured lipid carriers against multidrug resistance . Journal of Drug Targeting.|[2]Min Liu, et al. Intracellular delivery of 10-hydroxycamptothecin with targeted nanostructured lipid carriers against multidrug resistance. J Drug Target, Early Online: 1–8|[3]Yu P, et al. Synthesis and preliminary anticancer evaluation of 10-hydroxycamptothecin analogs. Biol Pharm Bull. 2012;35 (8) :1295-9.|[4]Zhang XW, et al. Differentiation-inducing action of 10-hydroxycamptothecin on human hepatoma Hep G2 cells. Acta Pharmacol Sin. 2000 Apr;21 (4) :364-8.|[5]Zhang XW, et al. Differential regulation of P53, c-Myc, Bcl-2, Bax and AFP protein expression, and caspase activity during 10-hydroxycamptothecin-induced apoptosis in Hep G2 cells. Anticancer Drugs. 2000 Oct;11 (9) :747-56.|[6]Liu M, et al. Intracellular delivery of 10-hydroxycamptothecin with targeted nanostructured lipid carriers against multidrug resistance. J Drug Target. 2016;24 (5) :433-40.

• Shipping Conditions:

  Room Temperature

• Storage Conditions:

  4°C (Powder, protect from light)

• Scientific Category:

  Natural Products

• Clinical Information:

  Phase 2

• Isoform:

  Topo I

• CAS Number:

  [19685-09-7]