TPE-MI (solution)

CAT: 0804-HY-DY1024-01Size: 50 μLDry Ice: NoHazardous: No
CAT#:0804-HY-DY1024-01Size:50 μL
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Description
TPE-MI (Tetraphenylethene maleimide) (solution) is a thiol probe for measuring unfolded protein load and proteostasis in cells (the excitation wavelength is 350 nm and the emission wavelength is 470 nm) . TPE-MI can report imbalances in proteostasis in induced pluripotent stem cell models of Huntington disease, as well as cells transfected with mutant Huntington exon 1 before the formation of visible aggregates. TPE-MI also detects protein damage following dihydroartemisinin research of the malaria parasitesPlasmodium falciparum [1][2].Solvent and concentration: DMSO: 10 mM
CAS Number
[1245606-71-6]
UNSPSC
12352005
Target
Huntingtin; Parasite
Related Pathways
Anti-infection; Neuronal Signaling
Field of Research
Infection; Neurological Disease
Smiles
O=C(C=C1)N(C2=CC=C(/C(C3=CC=CC=C3)=C(C4=CC=C(C)C=C4)/C5=CC=CC=C5)C=C2)C1=O
Molecular Formula
C31H23NO2
Molecular Weight
441.53
References & Citations
[1]Chen MZ, et al. A thiol probe for measuring unfolded protein load and proteostasis in cells. Nat Commun. 2017;8 (1) :474. Published 2017 Sep 7. |[2]Hu Q, et al. In Situ Monitored Vortex Fluidic-Mediated Protein Refolding/Unfolding Using an Aggregation-Induced Emission Bioprobe. Molecules. 2021;26 (14) :4273. Published 2021 Jul 14.
Shipping Conditions
Room temperature
Scientific Category
Dye Reagents
Clinical Information
No Development Reported

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