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Filipin complex (solution)

CAT: 0804-HY-DY1017-01Size: 200 µLDry Ice: NoHazardous: No
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CAT#:0804-HY-DY1017-01Size:200 µL
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Description
Filipin complex (solution) is a potent polyene macrolide antifungal antibiotic. Filipin complex inserts into membranes and sequester cholesterol into complexes and inhibits PRRSV entry. The Filipin complex consists of about 75.8% Filipin III , 10.8% Filipin IV, 9.1% Filipin II, and 1.2% Filipin I (Ex/Em = 380/430 nm)[2][3].Solvent and concentration: DMSO: 5 mg/mL
CAS Number
11078-21-0
UNSPSC
12352211
Target
Antibiotic; Fungal
Related Pathways
Anti-infection
Field of Research
Infection
Smiles
[Filipincomplex(solution)]
References & Citations
[1]Malcolm E. Bergy et al. Filipin complex. Biochemistry, 1968, 7, 2, 653-659.|[2]Houdai T, et al. Membrane-permeabilizing activities of amphidinol 3, polyene-polyhydroxy antifungal from a marine dinoflagellate. Biochim Biophys Acta. 2004 Nov 17;1667 (1) :91-100.|[3]Huang L, et al. Role of lipid rafts in porcine reproductive and respiratory syndrome virus infection in MARC-145 cells. Biochem Biophys Res Commun. 2011 Oct 28;414 (3) :545-50.|[4]Huang S, et al. Chimeric cerebral organoids reveal the essentials of neuronal and astrocytic APOE4 for Alzheimer's tau pathology. Signal Transduct Target Ther. 2022 Jun 13;7 (1) :176.
Shipping Conditions
Room temperature
Scientific Category
Dye Reagents
Clinical Information
No Development Reported

Chemical Information

Filipin

Filipin III is a macrolide that is the major component of a mixture of four isomeric polyene macrolides isolated from Streptomyces filipinensis. It has a role as a fluorescent probe and a bacterial metabolite. It is a macrolide, a polyol and an olefinic compound.

CAS Number11078-21-0
PubChem CID6433194
IUPAC Name(3R,4S,6S,8S,10R,12R,14R,16S,17E,19E,21E,23E,25E,27S,28R)-4,6,8,10,12,14,16,27-octahydroxy-3-[(1R)-1-hydroxyhexyl]-17,28-dimethyl-1-oxacyclooctacosa-17,19,21,23,25-pentaen-2-one
Molecular FormulaC35H58O11
Molecular Weight654.8
XLogP3.2
Topological Polar Surface Area208
Hydrogen Bond Donor Count9
Hydrogen Bond Acceptor Count11
Rotatable Bond Count5
Heavy Atom Count46
Formal Charge0
Complexity991
SMILES
CCCCC[C@H]([C@@H]1[C@H](C[C@H](C[C@H](C[C@H](C[C@H](C[C@H](C[C@@H](/C(=C/C=C/C=C/C=C/C=C/[C@@H]([C@H](OC1=O)C)O)/C)O)O)O)O)O)O)O)O
InChI
InChI=1S/C35H58O11/c1-4-5-11-16-31(42)34-33(44)22-29(40)20-27(38)18-25(36)17-26(37)19-28(39)21-32(43)23(2)14-12-9-7-6-8-10-13-15-30(41)24(3)46-35(34)45/h6-10,12-15,24-34,36-44H,4-5,11,16-22H2,1-3H3/b7-6+,10-8+,12-9+,15-13+,23-14+/t24-,25+,26-,27+,28-,29+,30+,31-,32+,33+,34-/m1/s1
InChIKey
IMQSIXYSKPIGPD-YQRUMEKGSA-N
Chemical Structure
2D Structure
2D structure of Filipin
CAS: 11078-21-0
CID: 6433194
Formula: C35H58O11
MW: 654.8
Interactive 3D Structure
Loading 3D structure...
View on PubChemRaw 3D data
Computed Properties
PropertyValue
Molecular Weight654.8
XLogP33.2
Hydrogen Bond Donor Count9
Hydrogen Bond Acceptor Count11
Rotatable Bond Count5
Exact Mass654.39791266
Monoisotopic Mass654.39791266
Topological Polar Surface Area208 Ų
Heavy Atom Count46
Formal Charge0
Complexity991
Isotope Atom Count0
Defined Atom Stereocenter Count11
Undefined Atom Stereocenter Count0
Defined Bond Stereocenter Count5
Undefined Bond Stereocenter Count0
Covalently-Bonded Unit Count1
Compound Is CanonicalizedYes

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