Filipin complex

• Description :

  Filipin complex is a potent polyene macrolide antifungal antibiotic. Filipin complex inserts into membranes and sequester cholesterol into complexes and inhibits PRRSV entry. The Filipin complex consists of about 75.8% Filipin III (HY-N6718), 10.8% Filipin IV, 9.1% Filipin II, and 1.2% Filipin I (Ex/Em = 380/430 nm) [1][2][3].

• UNSPSC :

  12171500

• Hazard Statement :

  H315, H319, H335

• Target :

  Antibiotic; Fungal

• Type :

  Dye Reagents

• Related Pathways :

  Anti-infection

• Field of Research :

  Infection

• Assay Protocol :

  https://www.medchemexpress.com/filipin-complex.html

• Purity :

  97.68

• Solubility :

  DMSO : ≥ 100 mg/mL|Ethanol : 10 mg/mL (ultrasonic; warming; heat to 60°C)

• Smiles :

  CCCCC[C@@H]([R1])[C@]1([H])[C@@H](O)C[C@@H](O)C[C@@H](O)C[C@@H](O)C[C@@H](O)C[C@@H](O)C[C@H](O)/C(C)=C/C=C/C=C/C=C/C=C/[C@H]([R2])[C@@H](C)OC1=O.[FilipinI:R1=H,R2=H1%FilipinII:R1=H,R2=OH9%FilipinIII:R1=(R)-OH,R2=OH76%FilipinIV:R1=(S)-OH,R2=OH11%]

• Precautions :

  H315, H319, H335

• References & Citations :

  [1]Malcolm E. Bergy et al. Filipin complex. Biochemistry, 1968, 7, 2, 653-659.|[2]Houdai T, et al. Membrane-permeabilizing activities of amphidinol 3, polyene-polyhydroxy antifungal from a marine dinoflagellate. Biochim Biophys Acta. 2004 Nov 17;1667 (1) :91-100.|[3]Huang L, et al. Role of lipid rafts in porcine reproductive and respiratory syndrome virus infection in MARC-145 cells. Biochem Biophys Res Commun. 2011 Oct 28;414 (3) :545-50.|[4]Huang S, et al. Chimeric cerebral organoids reveal the essentials of neuronal and astrocytic APOE4 for Alzheimer's tau pathology. Signal Transduct Target Ther. 2022 Jun 13;7 (1) :176.

• Shipping Conditions :

  Blue Ice

• Storage Conditions :

  -20°C (Powder, protect from light)

• Scientific Category :

  Dye Reagents

• Clinical Information :

  No Development Reported

• Isoform :

  Macrolide

• CAS Number :

  [11078-21-0]