Filipin complex

• UNSPSC Description:

  Filipin complex is a potent polyene macrolide antifungal antibiotic. Filipin complex inserts into membranes and sequester cholesterol into complexes and inhibits PRRSV entry. The Filipin complex consists of about 75.8% Filipin III (HY-N6718), 10.8% Filipin IV, 9.1% Filipin II, and 1.2% Filipin I[1][2][3].

• Target Antigen:

  Antibiotic; Fungal

• Type:

  Dye Reagents

• Related Pathways:

  Anti-infection

• Field of Research:

  Infection

• Assay Protocol:

  https://www.medchemexpress.com/filipin-complex.html

• Purity:

  97.68

• Solubility:

  DMSO : ≥ 100 mg/mL|Ethanol : 10 mg/mL (ultrasonic;warming;heat to 60°C)

• Smiles:

  CCCCC[C@@H]([R1])[C@]1([H])[C@@H](O)C[C@@H](O)C[C@@H](O)C[C@@H](O)C[C@@H](O)C[C@@H](O)C[C@H](O)/C(C)=C/C=C/C=C/C=C/C=C/[C@H]([R2])[C@@H](C)OC1=O.[Filipin I :R1=H,R2=H 1% Filipin II :R1=H,R2=OH 9% Filipin III :R1=(R)-OH,R2=OH 76% Filipin IV :R1=(S)-OH,R2=OH 11%]

• References & Citations:

  [1]Malcolm E. Bergy et al. Filipin complex. Biochemistry, 1968, 7, 2, 653-659.|[2]Houdai T, et al. Membrane-permeabilizing activities of amphidinol 3, polyene-polyhydroxy antifungal from a marine dinoflagellate. Biochim Biophys Acta. 2004 Nov 17;1667(1):91-100.|[3]Huang L, et al. Role of lipid rafts in porcine reproductive and respiratory syndrome virus infection in MARC-145 cells. Biochem Biophys Res Commun. 2011 Oct 28;414(3):545-50.

• Shipping Conditions:

  Blue Ice

• Storage Conditions:

  -20°C (Powder, protect from light)

• Clinical Information:

  No Development Reported

• CAS Number:

  11078-21-0