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BIBP3226 (TFA)

CAT: 0804-HY-107726-01Size: 5 mgDry Ice: NoHazardous: No
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CAT#:0804-HY-107726-01Size:5 mg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
BIBP3226 TFA is a potent and selective neuropeptide Y Y1 (NPY Y1) and neuropeptide FF (NPFF) receptor antagonist, with Kis of 1.1, 79, and 108 nM for rNPY Y1, hNPFF2, and rNPFF, respectively. BIBP3226 TFA displays anxiogenic-like effect[1][2].
CAS Number
1068148-47-9
UNSPSC
12352005
Hazard Statement
H302, H315, H319
Target
Neuropeptide Y Receptor
Type
Reference compound
Related Pathways
GPCR/G Protein; Neuronal Signaling
Applications
Neuroscience-Neuromodulation
Field of Research
Neurological Disease
Assay Protocol
https://www.medchemexpress.com/bibp3226-tfa.html
Purity
99.25
Solubility
DMSO : 250 mg/mL (ultrasonic)
Smiles
FC(C(O)=O)(F)F.OC(C=C1)=CC=C1CNC([C@@H](CCCNC(N)=N)NC(C(C2=CC=CC=C2)C3=CC=CC=C3)=O)=O
Molecular Formula
C29H32F3N5O5
Molecular Weight
587.59
Precautions
H302, H315, H319
References & Citations
[1]Mollereau C, et al. Agonist and antagonist activities on human NPFF (2) receptors of the NPY ligands GR231118 and BIBP3226. Br J Pharmacol. 2001 May;133 (1) :1-4.|[2]Kask A, et al. Anxiogenic-like effect of the neuropeptide Y Y1 receptor antagonist BIBP3226: antagonism with diazepam. Eur J Pharmacol. 1996 Dec 19;317 (2-3) :R3-4.
Shipping Conditions
Blue Ice
Storage Conditions
-80°C, 2 years; -20°C, 1 year (Powder, sealed storage, away from moisture and light)
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Isoform
NPY Y1 receptor

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