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Equilin-d2

CAT: 0804-HY-B1176S1Size: 1 EachDry Ice: NoHazardous: No
CAT#:0804-HY-B1176S1Size:1 Each
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
Equilin-d2 (7-Dehydroestrone-d2) is deuterium labeled Equilin. Equilin (7-Dehydroestrone) is an important member of the large group of oestrogenic substances and is chemically related to menformon (oestrone) . Equilin increases the growth of cortical neurons via an NMDA receptor-dependent mechanism[1][2].
Product Name Alternative
7-Dehydroestrone-d2
UNSPSC
12352005
Target
Estrogen Receptor/ERR; Isotope-Labeled Compounds
Related Pathways
Others; Vitamin D Related/Nuclear Receptor
Applications
Metabolism-protein/nucleotide metabolism
Field of Research
Endocrinology
Smiles
C[C@]1([C@](CC2([2H])[2H])([H])C3=CCC4=C(C=CC(O)=C4)[C@@]3([H])CC1)C2=O
Molecular Formula
C18H18D2O2
Molecular Weight
270.36
References & Citations
[1]Russak EM, et al. Impact of Deuterium Substitution on the Pharmacokinetics of Pharmaceuticals. Ann Pharmacother. 2019;53 (2) :211-216.|[2]David K, et al. Some biological properties of equilin. Biochem J. 1935;29 (2) :371-377.|[3]Brinton RD, et al. Equilin, a principal component of the estrogen replacement therapy premarin, increases the growth of cortical neurons via an NMDA receptor-dependent mechanism. Exp Neurol. 1997;147 (2) :211-220.|[4]Ito F, et al. Equilin in conjugated equine estrogen increases monocyte-endothelial adhesion via NF-κB signaling. PLoS One. 2019;14 (1) :e0211462. Published 2019 Jan 30.
Shipping Conditions
Room temperature
Scientific Category
Isotope-Labeled Compounds
Clinical Information
No Development Reported

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