Equilin

• Description :

  Equilin (7-Dehydroestrone) is an important member of the large group of oestrogenic substances and is chemically related to menformon (oestrone) . Equilin increases the growth of cortical neurons via an NMDA receptor-dependent mechanism[1][2].

• CAS Number :

  [474-86-2]

• Product Name Alternative :

  7-Dehydroestrone

• UNSPSC :

  12352005

• Hazard Statement :

  H302, H315, H319, H335

• Target :

  Estrogen Receptor/ERR

• Type :

  Reference compound

• Related Pathways :

  Vitamin D Related/Nuclear Receptor

• Field of Research :

  Endocrinology

• Assay Protocol :

  https://www.medchemexpress.com/Equilin.html

• Purity :

  99.91

• Solubility :

  DMSO : 100 mg/mL (ultrasonic) |Ethanol : 4 mg/mL (ultrasonic)

• Smiles :

  C[C@]1([C@](CC2)([H])C3=CCC4=C(C=CC(O)=C4)[C@@]3([H])CC1)C2=O

• Molecular Formula :

  C18H20O2

• Molecular Weight :

  268.35

• Precautions :

  H302, H315, H319, H335

• References & Citations :

  [1]David K, et al. Some biological properties of equilin. Biochem J. 1935;29 (2) :371-377.|[2]Brinton RD, et al. Equilin, a principal component of the estrogen replacement therapy premarin, increases the growth of cortical neurons via an NMDA receptor-dependent mechanism. Exp Neurol. 1997;147 (2) :211-220.|[3]Ito F, et al. Equilin in conjugated equine estrogen increases monocyte-endothelial adhesion via NF-κB signaling. PLoS One. 2019;14 (1) :e0211462. Published 2019 Jan 30.

• Shipping Conditions :

  Room Temperature

• Storage Conditions :

  -20°C, 3 years; 4°C, 2 years (Powder)

• Scientific Category :

  Reference compound1

• Clinical Information :

  No Development Reported