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Equilin-d4

CAT: 0804-HY-B1176S-01Size: 1 mgDry Ice: NoHazardous: No
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CAT#:0804-HY-B1176S-01Size:1 mg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
Equilin-d4 is the deuterium labeled Equilin. Equilin (7-Dehydroestrone) is an important member of the large group of oestrogenic substances and is chemically related to menformon (oestrone) . Equilin increases the growth of cortical neurons via an NMDA receptor-dependent mechanism[1][2].
CAS Number
285979-79-5
Product Name Alternative
7-Dehydroestrone-d4
UNSPSC
12352005
Hazard Statement
H302-H315-H319-H335
Target
Estrogen Receptor/ERR; Isotope-Labeled Compounds
Type
Isotope-Labeled Compounds
Related Pathways
Others; Vitamin D Related/Nuclear Receptor
Field of Research
Endocrinology
Solubility
10 mM in DMSO
Smiles
C[C@@]12[C@](CC([2H])([2H])C2=O)([H])C3=CCC4=C([2H])C(O)=C([2H])C=C4[C@@]3([H])CC1
Molecular Formula
C18H16D4O2
Molecular Weight
272.37
Precautions
P261-P264-P270-P271-P280-P302+P352-P304+P340-P305+P351+P338-P330-P362+P364-P403+P233-P405-P501
References & Citations
[1]Russak EM, et al. Impact of Deuterium Substitution on the Pharmacokinetics of Pharmaceuticals. Ann Pharmacother. 2019;53 (2) :211-216. |[2]David K, et al. Some biological properties of equilin. Biochem J. 1935;29 (2) :371-377.|[3]Brinton RD, et al. Equilin, a principal component of the estrogen replacement therapy premarin, increases the growth of cortical neurons via an NMDA receptor-dependent mechanism. Exp Neurol. 1997;147 (2) :211-220.|[4]Ito F, et al. Equilin in conjugated equine estrogen increases monocyte-endothelial adhesion via NF-κB signaling. PLoS One. 2019;14 (1) :e0211462. Published 2019 Jan 30.
Shipping Conditions
Room temperature
Scientific Category
Isotope-Labeled Compounds
Clinical Information
No Development Reported

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