Amiloride (Standard)

• Description:

  Amiloride (Standard) is the analytical standard of Amiloride. This product is intended for research and analytical applications. Amiloride (MK-870) is an inhibitor of both epithelial sodium channel (ENaC[1]) and urokinase-type plasminogen activator receptor (uTPA[2]) . Amiloride is a blocker of polycystin-2 (PC2; TRPP2[3]) channel.

• UNSPSC:

  12352100

• Target:

  Apoptosis; Reference Standards; Sodium Channel; TRP Channel

• Related Pathways:

  Apoptosis; Membrane Transporter/Ion Channel; Neuronal Signaling; Others

• Field of Research:

  Metabolic Disease; Cardiovascular Disease

• Smiles:

  O=C (C1=NC (Cl) =C (N) N=C1N) NC (N) =N

• Molecular Formula:

  C6H8ClN7O

• Molecular Weight:

  229.63

• References & Citations:

  [1]Ji, H.L., et al. delta ENaC: a novel divergent amiloride-inhibitable sodium channel. Am J Physiol Lung Cell Mol Physiol, 2012. 303 (12) : p. L1013-26.|[2]Teiwes J, et al. Epithelial sodium channel inhibition in cardiovascular disease. A potential role for amiloride. Am J Hypertens. 2007 Jan;20 (1) :109-17.|[3]Giamarchi A, et al. A polycystin-2 (TRPP2) dimerization domain essential for the function of heteromeric polycystin complexes. EMBO J. 2010 Apr 7;29 (7) :1176-91.

• Shipping Conditions:

  Room temperature

• Scientific Category:

  Reference Standards

• CAS Number:

  2609-46-3