Amiloride-15N3 (hydrochloride)

• UNSPSC Description:

  Amiloride-15N3 (hydrochloride) is the 15N labeled Amiloride hydrochloride[1]. Amiloride hydrochloride (MK-870 hydrochloride) is an inhibitor of both epithelial sodium channel (ENaC[2]) and urokinase-type plasminogen activator receptor (uTPA[3]). Amiloride hydrochloride is a blocker of polycystin-2 (PC2;TRPP2[4]) channel.

• Target Antigen:

  Apoptosis; Sodium Channel; TRP Channel

• Type:

  Isotope-Labeled Compounds

• Related Pathways:

  Apoptosis;Membrane Transporter/Ion Channel;Neuronal Signaling

• Applications:

  Neuroscience-Neurodegeneration

• Field of Research:

  Metabolic Disease

• Assay Protocol:

  https://www.medchemexpress.com/amiloride-15n3-hydrochloride.html

• Solubility:

  10 mM in DMSO

• Smiles:

  [15NH]=C([15NH2])[15NH]C(C1=NC(Cl)=C(N)N=C1N)=O.Cl

• Molecular Weight:

  269.07

• References & Citations:

  [1]Russak EM, et al. Impact of Deuterium Substitution on the Pharmacokinetics of Pharmaceuticals. Ann Pharmacother. 2019 Feb;53(2):211-216.|[2]Ji, H.L., et al. delta ENaC: a novel divergent amiloride-inhibitable sodium channel. Am J Physiol Lung Cell Mol Physiol, 2012. 303(12): p. L1013-26.|[3]Teiwes J, et al. Epithelial sodium channel inhibition in cardiovascular disease. A potential role for amiloride. Am J Hypertens. 2007 Jan20(1):109-17.|[4]Giamarchi A, et al. A polycystin-2 (TRPP2) dimerization domain essential for the function of heteromeric polycystin complexes. EMBO J. 2010 Apr 729(7):1176-91.

• Shipping Conditions:

  Room temperature

• Clinical Information:

  No Development Reported

• CAS Number:

  1216796-18-7