Amiloride hydrochloride dihydrate (Standard)

Amiloride hydrochloride dihydrate (Standard)

• CAS Number: 17440-83-4
• UNSPSC Description: Amiloride hydrochloride dihydrate (Standard) is the analytical standard of Amiloride hydrochloride dihydrate. This product is intended for research and analytical applications. Amiloride hydrochloride dihydrate (MK-870 hydrochloride dihydrate) is an inhibitor of both epithelial sodium channel (ENaC[1]) and urokinase-type plasminogen activator receptor (uTPA[2]). Amiloride hydrochloride dihydrate is a blocker of polycystin-2 (PC2; TRPP2[3]) channel.
• Target Antigen: Apoptosis; Sodium Channel; TRP Channel
• Type: Reference Standards
• Related Pathways: Apoptosis;Membrane Transporter/Ion Channel;Neuronal Signaling
• Field of Research: Metabolic Disease; Cardiovascular Disease
• Assay Protocol: https://www.medchemexpress.com/amiloride-hydrochloride-dihydrate-standard.html
• Smiles: O=C(C1=NC(Cl)=C(N)N=C1N)NC(N)=N.[H]Cl.O.O
• Molecular Weight: 302.12
• References & Citations: [1]Miller RL, et al. Blockade of ENaCs by amiloride induces c-Fos activation of the area postrema. Brain Res. 2015 Mar 19;1601:40-51.|[2]Xu LB, et al. Amiloride, a urokinase-type plasminogen activator receptor (uTPA) inhibitor, reduces proteinurea in podocytes. Genet Mol Res. 2015 Aug 14;14(3):9518-29.|[3]Giamarchi A, et al. A polycystin-2 (TRPP2) dimerization domain essential for the function of heteromeric polycystin complexes. EMBO J. 2010 Apr 7;29(7):1176-91.
• Shipping Conditions: Room temperature