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RU 56279

CAT: 0804-HY-77833-01Size: 100 mgDry Ice: NoHazardous: No
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CAT#:0804-HY-77833-01Size:100 mg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
RU 56279 is an androgen receptor (AR) antagonist with strong and systemic anti-androgenic activity. RU 56279 is also a common, potent and long-lasting anti-androgen metabolite of RU 56187 and RU 58841 (HY-10561) in vivo. RU 56279 can be used as an AR ligand to construct an AR-targeted prodrug system for the study of AR-positive tumor cells[1][2].
CAS Number
143782-20-1
UNSPSC
12352005
Hazard Statement
H302, H315, H319, H335
Target
Androgen Receptor; Drug Metabolite
Related Pathways
Metabolic Enzyme/Protease; Vitamin D Related/Nuclear Receptor
Applications
Metabolism-protein/nucleotide metabolism
Field of Research
Cancer; Endocrinology
Purity
99.68
Smiles
CC(C1=O)(C)NC(N1C2=CC(C(F)(F)F)=C(C#N)C=C2)=O
Molecular Formula
C13H10F3N3O2
Molecular Weight
297.23
Precautions
H302, H315, H319, H335
References & Citations
[1]Cousty-Berlin D, et al. Preliminary pharmacokinetics and metabolism of novel non-steroidal antiandrogens in the rat: relation of their systemic activity to the formation of a common metabolite. J Steroid Biochem Mol Biol. 1994 Oct;51 (1-2) :47-55.|[2]Cogan PS, Koch TH. Rational design and synthesis of androgen receptor-targeted nonsteroidal anti-androgen ligands for the tumor-specific delivery of a doxorubicin-formaldehyde conjugate. J Med Chem. 2003 Nov 20;46 (24) :5258-70.
Shipping Conditions
Room Temperature
Storage Conditions
-20°C, 3 years; 4°C, 2 years (Powder)
Scientific Category
Reference compound2
Clinical Information
No Development Reported

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