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SB-408124 (Standard)

CAT: 0804-HY-70068R-01Size: 5 mgDry Ice: NoHazardous: No
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CAT#:0804-HY-70068R-01Size:5 mg
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Description
SB-408124 (Standard) is the analytical standard of SB-408124. This product is intended for research and analytical applications. SB-408124 is a non-peptide OX1 receptor antagonist with Kis of 57 nM and 27 nM in whole cell and membrane, respectively. SB-408124 exhibits 50-fold selectivity over OX2 receptor[1].
CAS Number
288150-92-5
UNSPSC
12352100
Target
Orexin Receptor (OX Receptor) ; Reference Standards
Related Pathways
GPCR/G Protein; Neuronal Signaling; Others
Field of Research
Neurological Disease; Endocrinology
Smiles
O=C(NC1=CC(C)=NC2=C(C=C(C=C21)F)F)NC3=CC=C(C=C3)N(C)C
Molecular Formula
C19H18F2N4O
Molecular Weight
356.37
References & Citations
[1]Langmead CJ, et al. Characterisation of the binding of [3H]-SB-674042, a novel nonpeptide antagonist, to the human orexin-1 receptor. Br J Pharmacol. 2004;141 (2) :340-346.|[2]Kis GK, et al. The osmotically and histamine-induced enhancement of the plasma vasopressin level is diminished by intracerebroventricularly administered orexin in rats. Pflugers Arch. 2012;463 (4) :531-536.
Shipping Conditions
Room temperature
Scientific Category
Reference Standards

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