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SB 216763 (Standard)

CAT: 0804-HY-12012R-01Size: 5 mgDry Ice: NoHazardous: No
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CAT#:0804-HY-12012R-01Size:5 mg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
SB 216763 (Standard) is the analytical standard of SB 216763. This product is intended for research and analytical applications. SB 216763 is potent, selective and ATP-competitive GSK-3 inhibitor with IC50s of 34.3 nM for both GSK-3α and GSK-3β.
CAS Number
280744-09-4
UNSPSC
12352100
Target
Autophagy; GSK-3; Reference Standards
Related Pathways
Autophagy; Others; PI3K/Akt/mTOR; Stem Cell/Wnt
Field of Research
Neurological Disease; Cancer
Smiles
O=C(NC1=O)C(C2=CC=C(C=C2Cl)Cl)=C1C3=CN(C4=C3C=CC=C4)C
Molecular Formula
C19H12Cl2N2O2
Molecular Weight
371.22
References & Citations
[1]Gurrieri, et al. 3- (2,4-dichlorophenyl) -4- (1-methyl-1H-indol-3-yl) -1H-pyrrole-2,5-dione (SB216763), a glycogen synthase kinase-3 inhibitor, displays therapeutic properties in a mouse model of pulmonary inflammation and fibrosis. J.Pharmacol.Exp.Ther.2010|[2]Kirby LA, et al. Glycogen synthase kinase 3 (GSK3) inhibitor, SB-216763, promotes pluripotency in mouse embryonic stem cells.PLoS One. 2012;7 (6) :e39329. Epub 2012 Jun 26.|[3]Wang M, et al. The first synthesis of [ (11) C]SB-216763, a new potential PET agent for imaging of glycogen synthase kinase-3 (GSK-3) .Bioorg Med Chem Lett. 2011 Jan 1;21 (1) :245-9. Epub 2010 Nov 11.|[4]The ceiling effect of pharmacological postconditioning with the phytoestrogen genistein is reversed by the GSK3beta inhibitor SB 216763 [3- (2,4-dichlorophenyl) -4 (1-methyl-1H-indol-3-yl) -1H-pyrrole-2,5-dione] through mitochondrial ATP-dependent potassium channel opening.|[5]Coghlan MP, et al. Selective small molecule inhibitors of glycogen synthase kinase-3 modulate glycogen metabolism and gene transcription. Chem Biol. 2000 Oct;7 (10) :793-803.|[6]Wang W, et al. Inhibition of glycogen synthase kinase 3beta ameliorates triptolide-induced acute cardiac injury by desensitizing mitochondrial permeability transition. Toxicol Appl Pharmacol. 2016 Dec 15;313:195-203.
Shipping Conditions
Room temperature
Scientific Category
Reference Standards

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Alternative Products

CatalogName
366911-01SB 216763 (SB216763, SB-216763, SCHEMBL30251)
1769-5SB 216763
sc-200646SB-216763

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