Ispinesib (mesylate)

• Description :

  Ispinesib (SB-715992) mesylate is a specific inhibitor of kinesin spindle protein (KSP), with a Ki app of 1.7 nM.

• Product Name Alternative :

  SB-715992 (mesylate) ; CK-0238273 (mesylate)

• UNSPSC :

  12352005

• Target :

  Apoptosis; Kinesin

• Related Pathways :

  Apoptosis; Cell Cycle/DNA Damage; Cytoskeleton

• Field of Research :

  Cancer

• Solubility :

  10 mM in DMSO

• Smiles :

  O=C1N(CC2=CC=CC=C2)C([C@@H](C(C)C)N(CCCN)C(C3=CC=C(C)C=C3)=O)=NC4=CC(Cl)=CC=C14.OS(=O)(C)=O

• Molecular Formula :

  C31H37ClN4O5S

• Molecular Weight :

  613.17

• References & Citations :

  [1]Lad L, et al. Mechanism of inhibition of human KSP by ispinesib. Biochemistry. 2008 Mar 18;47 (11) :3576-85.|[2]Purcell JW, et al. Activity of the kinesin spindle protein inhibitor ispinesib (SB-715992) in models of breast cancer. Clin Cancer Res. 2010 Jan 15;16 (2) :566-76.|[3]Davis DA, et al. Increased therapeutic potential of an experimental anti-mitotic inhibitor SB715992 by genistein in PC-3 human prostate cancer cell line. BMC Cancer. 2006 Jan 24;6:22.

• Shipping Conditions :

  Room temperature

• Scientific Category :

  Reference compound1

• Clinical Information :

  No Development Reported

• Isoform :

  Kinesin-5/Eg5/KSP

• CAS Number :

  [514820-03-2]