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Ispinesib (mesylate)

CAT: 0804-HY-50759ASize: 1 EachDry Ice: NoHazardous: No
CAT#:0804-HY-50759ASize:1 Each
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Description
Ispinesib (SB-715992) mesylate is a specific inhibitor of kinesin spindle protein (KSP), with a Ki app of 1.7 nM.
CAS Number
[514820-03-2]
Product Name Alternative
SB-715992 (mesylate) ; CK-0238273 (mesylate)
UNSPSC
12352005
Target
Apoptosis; Kinesin
Related Pathways
Apoptosis; Cell Cycle/DNA Damage; Cytoskeleton
Field of Research
Cancer
Solubility
10 mM in DMSO
Smiles
O=C1N(CC2=CC=CC=C2)C([C@@H](C(C)C)N(CCCN)C(C3=CC=C(C)C=C3)=O)=NC4=CC(Cl)=CC=C14.OS(=O)(C)=O
Molecular Formula
C31H37ClN4O5S
Molecular Weight
613.17
References & Citations
[1]Lad L, et al. Mechanism of inhibition of human KSP by ispinesib. Biochemistry. 2008 Mar 18;47 (11) :3576-85.|[2]Purcell JW, et al. Activity of the kinesin spindle protein inhibitor ispinesib (SB-715992) in models of breast cancer. Clin Cancer Res. 2010 Jan 15;16 (2) :566-76.|[3]Davis DA, et al. Increased therapeutic potential of an experimental anti-mitotic inhibitor SB715992 by genistein in PC-3 human prostate cancer cell line. BMC Cancer. 2006 Jan 24;6:22.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Isoform
Kinesin-5/Eg5/KSP

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