Ispinesib (Standard)

• Description:

  Ispinesib (Standard) is the analytical standard of Ispinesib. This product is intended for research and analytical applications. Ispinesib is a specific inhibitor of kinesin spindle protein (KSP), with a Ki app of 1.7 nM.

• UNSPSC:

  12352100

• Target:

  Apoptosis; Kinesin; Reference Standards

• Related Pathways:

  Apoptosis; Cell Cycle/DNA Damage; Cytoskeleton; Others

• Field of Research:

  Cancer

• Smiles:

  O=C1N(CC2=CC=CC=C2)C([C@@H](C(C)C)N(CCCN)C(C3=CC=C(C)C=C3)=O)=NC4=CC(Cl)=CC=C14

• Molecular Formula:

  C30H33ClN4O2

• Molecular Weight:

  517.06

• References & Citations:

  [1]Lad L, et al. Mechanism of inhibition of human KSP by ispinesib. Biochemistry. 2008 Mar 18;47 (11) :3576-85.|[2]Purcell JW, et al. Activity of the kinesin spindle protein inhibitor ispinesib (SB-715992) in models of breast cancer. Clin Cancer Res. 2010 Jan 15;16 (2) :566-76.|[3]Davis DA, et al. Increased therapeutic potential of an experimental anti-mitotic inhibitor SB715992 by genistein in PC-3 human prostate cancer cell line. BMC Cancer. 2006 Jan 24;6:22.

• Shipping Conditions:

  Room temperature

• Scientific Category:

  Reference Standards

• CAS Number:

  [336113-53-2]