CI-1040 (Standard)

• Description :

  CI-1040 (Standard) is the analytical standard of CI-1040. This product is intended for research and analytical applications. CI-1040 (PD 184352) is an orally active, highly specific, small-molecule inhibitor of MEK with an IC50 of 17 nM for MEK1.

• CAS Number :

  [212631-79-3]

• UNSPSC :

  12352100

• Target :

  Apoptosis; MEK; Reference Standards

• Related Pathways :

  Apoptosis; MAPK/ERK Pathway; Others

• Field of Research :

  Cancer

• Smiles :

  O=C(C1=CC=C(C(F)=C1NC2=CC=C(I)C=C2Cl)F)NOCC3CC3

• Molecular Formula :

  C17H14ClF2IN2O2

• Molecular Weight :

  478.66

• References & Citations :

  [1]Allen LF, et al. CI-1040 (PD184352), a targeted signal transduction inhibitor of MEK (MAPKK) . Semin Oncol. 2003 Oct;30 (5 Suppl 16) :105-16.|[2]Wei CR, et al. MEK inhibitor CI-1040 induces apoptosis in acute myeloid leukemia cells in vitro. Eur Rev Med Pharmacol Sci. 2016 May;20 (10) :1961-8.|[3]Kramer BW, et al. Use of mitogenic cascade blockers for treatment of C-Raf induced lung adenoma in vivo: CI-1040strongly reduces growth and improves lung structure. BMC Cancer. 2004 Jun 1;4:24.

• Shipping Conditions :

  Room temperature

• Scientific Category :

  Reference Standards