CI-986

• Description :

  CI-986 is a dual inhibitor of COX and 5-LOX. CI-986 can prevent the coronary vasoconstriction and the increased production of LTB (4) and LTC (4) . CI-986 also has anti-inflammatory and analgesic effects. CI-986 can be used for the researches of inflammation and cardiovascular disease, such as arthritis[1][2].

• CAS Number :

  [130116-16-4]

• UNSPSC :

  12352005

• Target :

  COX; Lipoxygenase

• Related Pathways :

  Immunology/Inflammation; Metabolic Enzyme/Protease

• Field of Research :

  Inflammation/Immunology; Cardiovascular Disease

• Smiles :

  [O-]C1=C(C(C)(C)C)C=C(C2=NNC(S2)=S)C=C1C(C)(C)C.OCC[N+](C)(C)C

• Molecular Formula :

  C21H35N3O2S2

• Molecular Weight :

  425.65

• References & Citations :

  [1]Gök S, et al. Role of leukotrienes on coronary vasoconstriction in isolated hearts of arthritic rats: effect of in vivo treatment with CI-986, a dual inhibitor of cyclooxygenase and lipoxygenase. Pharmacology. 2000 Jan;60 (1) :41-6.|[2]Schrier DJ, et al. The pharmacologic effects of 5-[3,5-bis (1,1-dimethylethyl) -4- hydroxyphenyl]-1,3,4-thiadiazole-2 (3H) -thione, choline salt (CI-986), a novel inhibitor of arachidonic acid metabolism in models of inflammation, analgesia and gastric irritation. Prostaglandins. 1994 Jan;47 (1) :17-30.

• Shipping Conditions :

  Room temperature

• Scientific Category :

  Reference compound1

• Clinical Information :

  No Development Reported

• Isoform :

  5-LOX