AKT ligand-2

CAT: 0804-HY-48682Size: 1 EachDry Ice: NoHazardous: No

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Description

AKT ligand-2 (compound 5) is an AKT ligand. AKT ligand-2 can be combined with VHL ligand (S, R, S) -AHPC through linker to synthesize PROTAC MS21 (HY-141807).

CAS Number

2376139-61-4

UNSPSC

12352005

Target

Ligands for Target Protein for PROTAC

Related Pathways

PROTAC

Field of Research

Cancer

Smiles

ClC(C=C1)=CC=C1[C@H](CCN2CCNCC2)NC(C3(CCN(C4=C5C(NC=C5)=NC=N4)CC3)NC(OC(C)(C)C)=O)=O

Molecular Formula

C30H41ClN8O3

Molecular Weight

597.15

References & Citations

[1]Xu J, et al. AKT Degradation Selectively Inhibits the Growth of PI3K/PTEN Pathway-Mutant Cancers with Wild-Type KRAS and BRAF by Destabilizing Aurora Kinase B. Cancer Discov. 2021 Dec

Shipping Conditions

Room temperature

Scientific Category

Reference compound2

Clinical Information

No Development Reported

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AKT ligand-2

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